A long-term follow-up study on the relationship of social and lifestyle factors in childhood to cardiovascular risk factors in adulthood

儿童期社会和生活方式因素与成年期心血管危险因素关系的长期随访研究

• 批准号: 16590519
• 负责人: MIURA Katsuyuki
• 金额: $ 2.11万
• 依托单位: KANAZAWA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590519/
• 关键词: baby; social factors; lifestyle; blood pressure; serum cholesterol; birth weight; epidemiology

Lower birth weight has been repeatedly reported to be related to adverse cardiovascular risk factors and cardiovascular disease morbidity and mortality in adulthood. However, it has not been fully investigated whether social and lifestyle factors before and after birth affect this relationship. This is a 20-year follow-up study in 5,000 men and women to investigate the relationship of social and lifestyle factors at birth and in childhood to cardiovascular risk factors (blood pressure, serum cholesterol, and body mass index) at the age of 20.Information on social factors (age, education, and occupation of mother and father ; housing, etc.) and lifestyle factors (breast feeding, etc.) were obtained in babies who were born in 1965-1974. The information was linked to health examination data at the age of 20.Main results were : (1)A significant inverse relationship between birth weight and blood pressure at 20 years was attenuated by adjustment of education of father. (2)A significant inverse relationship between birth weight and serum cholesterol at 20 years in men did not change by adjustment of social factors. (3)In men, lower education of mother was related to higher blood pressure at 20 years. (4)In men, living with grand father and grand mother in childhood was related to higher blood pressure at 20 years. (5)In men, having mother aged 35 or over at birth and mother with higher education was related to lower cholesterol at 20 years. (6)Women who were grown up mainly by grand mother had higher cholesterol at 20 years.The results showed that the relationship between birth weight and cardiovascular risk factors in adult life was affected by some social factors at birth and in childhood, and that some social factors were independently related to cardiovascular risk factors in adulthood.

出生体重过轻与不良心血管危险因素和成年期心血管疾病发病率和死亡率有关。然而，还没有充分调查出生前后的社会和生活方式因素是否会影响这种关系。这是一项对5,000名男性和女性进行的20年随访研究，旨在调查出生时和儿童期的社会和生活方式因素与20岁时心血管危险因素（血压、血清胆固醇和体重指数）的关系。和生活方式因素（母乳喂养等）是在1965-1974年出生的婴儿中获得的。结果表明：（1）出生体重与20岁时血压呈显著负相关，但随着父亲受教育程度的调整，这种负相关逐渐减弱。(2)A男性出生体重与20岁时血清胆固醇之间的显著负相关关系并不因社会因素的调整而改变。(3)In男性，母亲文化程度低与20岁时血压升高有关。(4)In男性，童年时与祖父母生活在一起，与20岁时的高血压有关。(5)In男性，出生时母亲年龄在35岁或以上，母亲受过高等教育，与20岁时的低胆固醇有关。（6）以祖母抚养为主的妇女20岁时胆固醇水平较高。结果表明，出生体重与成年期心血管危险因素的关系受出生时和儿童期社会因素的影响，某些社会因素与成年期心血管危险因素独立相关。