Role of macrophages in the development and repair of renal injury

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Tubulointerstitial fibrosis is a main determinant that leads to an irreversible loss of renal function in chronic diseases. The present study was conducted to elucidate the role of mononuclear phagocyte system in the development and repair of renal injury by using mouse unilateral ureteral obstruction. It was found in this animal model that mononuclear phagocytes but not dendritic cells were involved in the development of fibrosis whereas the contribution of these mononuclear phagocytes became less with progression of the disease despite the increase in number of the infiltrating mononuclear cells.