Multi-center epidemiologic study on dietary and urinary selenium and blood pressure

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This study is to investigate the relationship of dietary intake, serum concentration and urinary excretion of selenium to blood pressure in 4 adult Japanese populations. The study was conducted as a part of the INTERMAP, an international cooperative study on nutrients and blood pressure among four countries.About 300 men and women aged 40-59 were randomly selected from each of 4 populations ; 3 worksites in Toyama, Wakayama, Hokkaido, and one town in Shiga. A total of 1,145 participants (574 men and 571 women) were measured their blood pressure by highly standardized method using random zero sphygmomanometer, had 4 dietary survey using 24 hour recall method, and had 2 set of 24 hour urinary collection. Dietary selenium intake was calculated using INTERMAP Japan food tables. Urinary selenium concentration was measured, and 24 hour urinary excretion of selenium was calculated. Serum selenium concentration was measured in subsamples.Mean dietary selenium intake was estimated to be 191mcg/day in men and 151mcg/day in women. The intake was more in subjects aged 50's than in those aged 40's. Intake density of selenium was approximately 85mcg/1000kcal, which was similar between men and women. Mean 24 hour urinary excretion of selenium was estimated to be 139mcg in men and 116mcg in women, where 73-77% of dietary intake was estimated to be excreted in urine. Serum selenium concentration was not correlated significantly with urinary excretion or dietary intake of selenium.In multiple regression analyses, blood pressure was not significantly related with urinary selenium excretion or dietary selenium intake density both in men and in women, after adjustment for possible confounders.