Multi-center epidemiologic study on dietary and urinary selenium and blood pressure

本研究旨在探讨日本4个成年人群膳食硒摄入量、血清硒浓度和尿硒排泄量与血压的关系。这项研究是INTERMAP的一部分，INTERMAP是一项关于营养和血压的四个国家的国际合作研究。从4个人群中随机抽取约300名年龄在40-59岁之间的男女；北海道和歌山富山3个工地，滋贺1个镇。1145名参与者（男性574人，女性571人）采用高度标准化的随机零血压计测量血压，采用24小时回忆法进行4次饮食调查，并进行2组24小时尿液收集。膳食硒摄入量采用日本INTERMAP食品表计算。测定尿硒浓度，计算24小时尿硒排泄量。测定各亚样品血清硒浓度。平均膳食硒摄入量估计为男性191微克/天，女性151微克/天。50岁的人比40岁的人摄入更多。硒的摄入密度约为85微克/1000千卡，男女之间基本相同。据估计，男性24小时平均尿硒排泄量为139微克，女性为116微克，其中膳食摄入量的73-77%通过尿液排出。血清硒浓度与尿排泄或膳食硒摄入量无显著相关。在多元回归分析中，在对可能的混杂因素进行校正后，血压与男性和女性尿硒排泄量或膳食硒摄入密度均无显著相关性。

This study is to investigate the relationship of dietary intake, serum concentration and urinary excretion of selenium to blood pressure in 4 adult Japanese populations. The study was conducted as a part of the INTERMAP, an international cooperative study on nutrients and blood pressure among four countries.About 300 men and women aged 40-59 were randomly selected from each of 4 populations ; 3 worksites in Toyama, Wakayama, Hokkaido, and one town in Shiga. A total of 1,145 participants (574 men and 571 women) were measured their blood pressure by highly standardized method using random zero sphygmomanometer, had 4 dietary survey using 24 hour recall method, and had 2 set of 24 hour urinary collection. Dietary selenium intake was calculated using INTERMAP Japan food tables. Urinary selenium concentration was measured, and 24 hour urinary excretion of selenium was calculated. Serum selenium concentration was measured in subsamples.Mean dietary selenium intake was estimated to be 191mcg/day in men and 151mcg/day in women. The intake was more in subjects aged 50's than in those aged 40's. Intake density of selenium was approximately 85mcg/1000kcal, which was similar between men and women. Mean 24 hour urinary excretion of selenium was estimated to be 139mcg in men and 116mcg in women, where 73-77% of dietary intake was estimated to be excreted in urine. Serum selenium concentration was not correlated significantly with urinary excretion or dietary intake of selenium.In multiple regression analyses, blood pressure was not significantly related with urinary selenium excretion or dietary selenium intake density both in men and in women, after adjustment for possible confounders.