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Longitudinal study of the low risk of cerebrovascular disease in cancer patients in the cohort of A-bomb survivors

原子弹幸存者队列中癌症患者脑血管疾病低风险的纵向研究

基本信息

批准号：
16590531
负责人：
SUYAMA Akihiko
金额：
$ 2.3万
依托单位：
Radiation Effects Research Foundation
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590531/
关键词：
multiple disease cerebrovascular disease malignant neoplasm 脳血管疾患

项目摘要

This study is planned in view of the previous study demonstrated that malignant neoplasm and cerebrovascular disease have such common risk factors as unhealthy diet, smoking, and excessive alcohol intake, and when stomach or lung cancer was present as the primary disease, the risk of development of cerebrovascular disease as the secondary disease was significantly low, and when cerebrovascular disease was present as the primary disease, the risk of development of malignant neoplasm was significantly high. Tuomilehto et al.(1984) reported that cancer and stroke risk increased together in Finland study and it might be able to explain by common risk factor, 'salt'. But Whelton et al.(1982) did not assisted that hypothesis. By recent decade, there are several reports as for the secondary risk of gastric cancer and stroke, But they did not still meet with same results.The RERF cohort study has been conducted prospectively for about 50 years to follow up the mortality and cancer incidence of A-bomb surviors. So that mortality risk is considered much reliable based on the high sopysiticated epidemiological method and scientific activity. Their life style information have been obtained by the past several mail surveys.Current report as to Life Span Study has been already published as LSS 13 and several cancer ERR and EAR has been still significant among LSS cohort.Non-cancer disease's risk, expecially cardiovascular disease, might be significant among Adult Health Study chohort.This report is based on recent reports shown above and the analysis is also conducted to find the secondary risk between cancer and stroke.

本研究是针对已有研究表明，恶性肿瘤和脑血管疾病具有不健康饮食、吸烟、过量饮酒等共同危险因素，以胃癌、肺癌为原发病时，发生脑血管疾病为继发性疾病的风险明显较低，而当以脑血管疾病为原发病时，发生恶性肿瘤的风险明显较高。Tuomilehto等人(1984)报告说，在芬兰的一项研究中，癌症和中风的风险同时增加，这可能能够用共同的风险因素“盐”来解释。但Whelton等人(1982)并没有支持这一假设。近十年来，关于胃癌和中风的继发风险已经有了一些报道，但仍然没有得到相同的结果。RERF队列研究已经前瞻性地进行了大约50年，以追踪原子弹幸存者的死亡率和癌症发病率。因此，基于高度致病的流行病学方法和科学活动，死亡风险被认为是非常可靠的。他们的生活方式信息是通过过去的几次邮件调查获得的。目前关于寿命研究的报告已经发表在LSS 13中，一些癌症错误和耳朵在LSS队列中仍然很重要。非癌症疾病的风险，特别是心血管疾病，在成人健康研究队列中可能是重要的。本报告基于上述最近的报告，并进行了分析，以发现癌症和中风之间的次要风险。