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Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline

Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline
临床前阿尔茨海默病、脑血管疾病和认知能力下降中的蓝斑成像标志物
批准号：
10661433
负责人：
Mark W Bondi
金额：
$162.4万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-04-01 至 2028-03-31
来源：
https://reporter.nih.gov/project-details/10661433
关键词：
Adrenergic AgentsAfrican AmericanAgeAlzheimer&aposs DiseaseAmericanAmyloidAsian AmericansAstrocytesBlack raceBlood VesselsBrain StemBrain imagingBrain regionCell NucleusCellsCerebrovascular DisordersCerebrumClinicalCognitionCognitiveCollaborationsCross-Sectional StudiesDementiaDisease ProgressionEarly InterventionEducationElderlyEnvironmentEthnic PopulationGeneticGeographyGoalsHemorrhageImpaired cognitionInstitutionInterventionKnowledgeLate Onset Alzheimer DiseaseLatinxLesionLinkLongitudinal StudiesMagnetic Resonance ImagingMedialMemoryMethodsNerve DegenerationNeuronsNeuropsychologyNon-linear ModelsNorepinephrineOutcomeParticipantPathologicPerfusionPlasmaPlayPositioning AttributePredictive ValueProtocols documentationResearch PersonnelResourcesRiskRoleSamplingSignal TransductionSiteSourceStimulusStructureTauopathiesThickTimeVascular Diseasesapolipoprotein E-4autosomal dominant Alzheimer&aposs diseasecaucasian Americancerebrovascularcognitive functioncohortdementia riskdemographicsethnic diversityexperiencefollow-upgenetic risk factorhealthy agingimaging biomarkerinnovationlocus ceruleus structuremagnetic resonance imaging biomarkermild cognitive impairmentmultimodalityneuropathologypre-clinicalpredictive markerracial diversityracial populationselective attentionsexsynucleinopathytau Proteinstau mutationvascular factorvascular risk factorwhite matter

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Project Summary The proposed study will investigate brain imaging markers of a small brainstem nucleus called the locus coeruleus, which is important for cognitive function and is the first brain region to show Alzheimer’s disease- related changes in older adults who go on develop dementia. The study will examine brain imaging locus coeruleus markers in older adults who go on to have a healthy aging experience over time and in those who go on to develop Alzheimer’s disease, cerebrovascular disease and cognitive decline. By comparing the trajectory of changes in brain imaging markers of the locus coeruleus, we can better understand the potential value of these imaging markers for tracking disease progression from a very early stage.
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Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease
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New Quantitative Neuroimaging Metrics of Structural and Functional Connectivity of the Locus Coeruleus as a Novel Biomarker of Alzheimer's Disease Pathogenesis and Progression
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