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Development of the noninvasive brain function diagnostic procedure using magnetoencephalography for the purpose of foreseeing the onset of cerebral ischemia

开发利用脑磁图的无创脑功能诊断程序，以预测脑缺血的发生

基本信息

批准号：
16590842
负责人：
TSUYUGUCHI Naohiro
金额：
$ 1.79万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

Clinical researches of MEG and PETWe performed 015 gas PET, which measured cerebral blood flow(CBF) and oxygen extraction fraction(OEF), and magnetoencephalography which measured evoked magnetic field for cerebrovascular disorder 25 examples. Furthermore, we measured spontaneous magnetic field of brain and analyzed the frequency using spatial filter technique(beam former). The results showed correlation of dipole moment of N20m and OEF. Beam former showed 0 and 6 activity in the ischemic area. Especialy, 0 activity correlated OEF increased lesion.Fundamental researches of MEGWe developed SQUID magneto meter array of nine channels which did integration on a silicon chip for the purpose of small animal's magnetic field. (the sensor array have nine 2.5mm (I) SQUID magneto meters arranged in the shape of 3 X 3 matrices every 2.75mm, and total size is 10 X 10mm.). We set this magnetometor in small shield box which set in a shield room. We could reproducibility measure visual evoked field and auditory evoked field of rat brain using this instrument, but could not detect somatosensory evoked field.Fundamental researches of PETWe made a cerebral ischemia model of rat brain and measured carbohydrate metabolism using micro PET. We compared PET image with autoradiograph in small ischemic area of middle cerebral artery, and PET could enough detect its lesion. We measured brain glucose metabolism by electric stimulation of peripheral nerve, but were not able to detect clear change. However, the lesion was depicted in autoradiograph distinctly. It is thought that there is limitation for analysis of rat brain in micro PET with an aspect of quantitative evaluation..

MEG和PET的临床研究我们进行了015气体PET，测量脑血流量（CBF）和氧提取分数（OEF），以及脑磁图测量脑血管疾病的诱发磁场25例。此外，我们测量了大脑的自发磁场，并使用空间滤波器技术（波束形成器）分析了频率。结果显示了N20m偶极矩与OEF的相关性。波束形成器在缺血区域显示出 0 和 6 活性。特别是，0活动相关的OEF增加了病变。MEG的基础研究我们开发了九通道的SQUID磁力计阵列，将其集成在硅芯片上，用于小动物的磁场。（传感器阵列有9个2.5mm（I）SQUID磁力计，每2.75mm排列成3 X 3矩阵，总尺寸为10 X 10mm。）。我们将这个磁力计放置在屏蔽室中的小屏蔽盒中。利用该仪器可以重复性地测量大鼠脑的视觉诱发场和听觉诱发场，但不能检测体感诱发场。PET的基础研究我们制作了大鼠脑缺血模型，并利用微型PET测量了碳水化合物代谢。我们将大脑中动脉小面积缺血区域的PET图像与放射自显影进行比较，PET足以发现其病变。我们通过电刺激周围神经来测量大脑葡萄糖代谢，但未能检测到明显的变化。然而，放射自显影清楚地描绘了病变。人们认为，在定量评估方面，显微 PET 对大鼠大脑的分析存在局限性。