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Control of salivary secretion through gap junctional communication

通过间隙连接通讯控制唾液分泌

基本信息

批准号：
16591857
负责人：
SHIBA Yoshiki
金额：
$ 2.05万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591857/
关键词：
salivary secretion gap junction cell communication salivary gland amylase secretion acinus duct ギヤップ結合

项目摘要

The autonomic nerve system regulates the secretory function of the salivary gland in which gap junctional cell communication is well developed. We investigated the control mechanism of secretory function through the cell communication, and obtained the following results.1 Cell communication inhibitor suppressed amylase release with autonomic nervous agonists in tissue strips of the parotid.2 Cell communication inhibitor suppressed peroxidase secretion with the field electrical stimulation in the tissue strips of the submandibular glands.3 Cell communication inhibitor induced exocytotic morphology in some acinar cells and enhanced fluid secretion-related morphology, but it did not change the stimulated duct morphology.4 Cell communication inhibitor restricted the increase in [Ca2+]i in some acinar cells, although calcium wave is propagated in many acinar cells.5 The amylase secretion and fluid secretion-related morphology in the tissue strips was suppressed with cytochalasin, but not markedly with many types of kinase inhibitors.6 Capillary network encircled a group of acini connected with the ducts. Nerve terminals were rarely observed in the surface of the acinar cells.7 Oscillatory secretion currents in clumps of acinar cells exhibited a few kinds of intensity, and cell communication inhibitor treatment induced the uniform intensity currents.Gap junctional cell communication contributes to the salivary secretion through signal transfer compensated the rare distribution of nerve innervation.

自主神经系统调节唾液腺的分泌功能，其中间隙连接细胞通讯发达。我们通过细胞通讯研究了分泌功能的控制机制，得到了以下结果：1细胞通讯抑制剂通过自主神经激动剂抑制腮腺组织条中淀粉酶的释放。2细胞通讯抑制剂通过场电刺激下颌下腺组织条抑制过氧化物酶的分泌。3细胞通讯抑制剂诱导一些腺泡细胞的胞吐形态并增强液体 4 细胞通讯抑制剂限制了一些腺泡细胞中 [Ca2+]i 的增加，尽管钙波在许多腺泡细胞中传播。 5 组织条中淀粉酶分泌和液体分泌相关的形态被细胞松弛素抑制，但许多类型的激酶抑制剂不明显。 6 毛细管网络周围环绕着一组与导管相连的腺泡。腺泡细胞表面很少观察到神经末梢。7腺泡细胞团中的振荡分泌电流表现出几种强度，细胞通讯抑制剂处理诱导了均匀强度的电流。间隙连接细胞通讯通过信号传递补偿神经支配的罕见分布，有助于唾液分泌。