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Pathogenesis of polypoidal choroidal vasculopathy focusing on the extracellular matrix

息肉状脉络膜血管病变的发病机制聚焦于细胞外基质

基本信息

批准号：
17591844
负责人：
OKUBO Akiko
金额：
$ 2.3万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591844/
关键词：
polypoidal choroidal vasculopathy pathogenesis treatment

项目摘要

[Background and Purpose]Polypoidal choroidal vasculopathy (PCV) is characterized by branching choroidal vessels with polyp-like terminal aneurismal dilations. Clinically, the vascular abnormality appears to be in the inner choroid and is composed of 2 basic elements: a polypoidal vessel and a branching vascular network. Although PCV is known to have a predilection for Asian populations, the exact pathology of it remains unclear and there are no current treatment guidelines. In this study, we aimed to evaluate choroidal vasculature and find efficient treatments for patients with PCV.[Results]1. Features o: vessels in PCV(1) Pulsatile blood flowWe reviewed our series of cases of PCV with pulsatile polypoidal vessels and evaluated the features of such vessels in PCV. it is a unique and important characteristic that has not been reported with any other chorio-retinal diseases. (Ophthalmology, 112:1436-41, 2005)(2) Diversity in PCVWe investigated the clinical features of PCV, in terms of le … More sion size and disease duration, during earlier and later disease stages and found differences between the groups. The results suggest that there may be subgroups in PCV; these subgroups are based or different pathologies but manifest similar polypoidal structures. Long-term observation of small-short cases could resolve his uncertainty. Further studies incorporating pathologies and treatments are required. (submitted)2. Effect of Injection of triamcinolone acetonide (TA) for exudative age related macular degeneration / PCVWe evaluated the effect of intravitreal / sub-Tenon TA with exudative age related macular degeneration (AMD)/ PCV. Intravitreal TA provided short-term improvement in visual acuity and fundus findings in exudative AMD without significant side effects such as intraocular pressure increase and endophthalmitis. (Ophthalmologica, 220:118-24, 2006)Trans-Tenon's retrobulbar TA injection may be a potential option for treating PCV from the point of view of effectiveness, safety, and cost. (Graefe's Archive for Clinical and Experimental Ophthalmology, 243:837-9, 2005) Less

【背景与目的】息肉样脉络膜血管病变（Polypoidal choroidal vascular pathy， PCV）以脉络膜血管分支伴息肉样末梢动脉瘤扩张为特征。临床上，血管异常出现在脉络膜内，由2个基本元素组成：息肉状血管和分支血管网。虽然已知PCV对亚洲人群有偏爱，但其确切病理尚不清楚，目前也没有治疗指南。在本研究中，我们旨在评估脉络膜血管系统，并寻找有效的治疗方法。(1)搏动性血流我们回顾了一系列伴有搏动性息肉样血管的PCV病例，并评价了这种血管在PCV中的特征。这是一个独特的和重要的特征，没有报道与任何其他绒毛膜-视网膜疾病。(2) PCV的多样性我们研究了PCV在疾病早期和晚期的临床特征，包括体积大小和病程，并发现了组间的差异。结果提示PCV可能存在亚群；这些亚群是基于或不同的病理，但表现出类似的息肉状结构。长期观察小-短病例可以解决他的不确定性。需要进一步的结合病理和治疗的研究。(提交)2。曲安奈德（triamcinolone acetonide， TA）治疗渗出性年龄相关性黄斑变性（macular degeneration， AMD）/ PCV的疗效评价：玻璃体内注射TA治疗渗出性年龄相关性黄斑变性（macular degeneration， AMD）/ PCV的疗效。玻璃体内TA可在短期内改善渗出性AMD患者的视力和眼底表现，且无眼压升高和眼内炎等明显副作用。（眼科学，220:118- 24,2006）从有效性、安全性和成本的角度来看，Trans-Tenon的球后TA注射可能是治疗PCV的潜在选择。(《临床与实验眼科学档案》，243:837-9,2005

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

年龄相关性黄斑变性（玻璃体内注射曲安奈德治疗的病例报告）。

DOI：
发表时间：
2006
期刊：
Folia Ophthalmol 57 (1)
影响因子：
0
作者：
Sonoda S;Tachibana K;Uchino E;Okubo A;Yamamoto M;Sakoda K;Hisatomi T;Sonoda KH;Negishi Y;Izumi Y;Takao S;Sakamoto T;Okubo A
通讯作者：
Okubo A

黄斑疾患の診断と治療加齢黄斑変性(トリアムシノロン硝子体腔内注入を行った症例)

黄斑部疾病的诊断和治疗年龄相关性黄斑变性（玻璃体内注射曲安西龙的病例）