Pathogenesis of polypoidal choroidal vasculopathy focusing on the extracellular matrix

【背景与目的】息肉状脉络膜血管病变（polypoidalchoroidalvasculopathy，PCV）是以脉络膜血管分支和息肉样终末血管扩张为特征的一种疾病。临床上，血管异常似乎是在脉络膜内部，并由2个基本要素组成：息肉状血管和分支血管网。虽然已知PCV对亚洲人群有偏好，但其确切的病理学尚不清楚，目前也没有治疗指南。在这项研究中，我们的目的是评估脉络膜血管，并找到有效的治疗PCV患者。[结果]1.产品特点：PCV内的血管（1）搏动性血流我们回顾了我们的PCV内搏动性息肉样血管的病例，并对PCV内搏动性息肉样血管的特点进行了评价。这是一个独特而重要的特征，在任何其他脉络膜视网膜疾病中都没有报道过。（Ophthalmology，112：1436-41，2005）（2）PCV的多样性我们研究了PCV的临床特征， ...更多信息 锡永和疾病持续时间，在早期和晚期疾病阶段，并发现组间差异。结果表明PCV可能存在亚组;这些亚组基于不同的病理，但表现出相似的息肉状结构。长期观察小短病例，可以解决他的疑惑。需要进一步的研究，包括病理和治疗。（已提交）2.曲安奈德（TA）注射治疗渗出型老年性黄斑变性（AMD）/PCV的疗效观察我们评价了玻璃体内/Tenon下TA治疗渗出型AMD/ PCV的疗效。玻璃体内TA可在短期内改善渗出性AMD患者的视力和眼底表现，而无明显副作用，如眼内压升高和眼内炎。（Ophthalmologica，220：118-24，2006）从有效性、安全性和成本的角度来看，经眼球后TA注射可能是治疗PCV的潜在选择。（Graefe's Archive for Clinical and Experimental Ophthalmology，243：837-9，2005）减

[Background and Purpose]Polypoidal choroidal vasculopathy (PCV) is characterized by branching choroidal vessels with polyp-like terminal aneurismal dilations. Clinically, the vascular abnormality appears to be in the inner choroid and is composed of 2 basic elements: a polypoidal vessel and a branching vascular network. Although PCV is known to have a predilection for Asian populations, the exact pathology of it remains unclear and there are no current treatment guidelines. In this study, we aimed to evaluate choroidal vasculature and find efficient treatments for patients with PCV.[Results]1. Features o: vessels in PCV(1) Pulsatile blood flowWe reviewed our series of cases of PCV with pulsatile polypoidal vessels and evaluated the features of such vessels in PCV. it is a unique and important characteristic that has not been reported with any other chorio-retinal diseases. (Ophthalmology, 112:1436-41, 2005)(2) Diversity in PCVWe investigated the clinical features of PCV, in terms of le … More sion size and disease duration, during earlier and later disease stages and found differences between the groups. The results suggest that there may be subgroups in PCV; these subgroups are based or different pathologies but manifest similar polypoidal structures. Long-term observation of small-short cases could resolve his uncertainty. Further studies incorporating pathologies and treatments are required. (submitted)2. Effect of Injection of triamcinolone acetonide (TA) for exudative age related macular degeneration / PCVWe evaluated the effect of intravitreal / sub-Tenon TA with exudative age related macular degeneration (AMD)/ PCV. Intravitreal TA provided short-term improvement in visual acuity and fundus findings in exudative AMD without significant side effects such as intraocular pressure increase and endophthalmitis. (Ophthalmologica, 220:118-24, 2006)Trans-Tenon's retrobulbar TA injection may be a potential option for treating PCV from the point of view of effectiveness, safety, and cost. (Graefe's Archive for Clinical and Experimental Ophthalmology, 243:837-9, 2005) Less