Pathogenesis of polypoidal choroidal vasculopathy focusing on the peculiarity of chorotial vessels

息肉状脉络膜血管病变的发病机制聚焦于脉络膜血管的特殊性

基本信息

  • 批准号:
    15591866
  • 负责人:
  • 金额:
    $ 2.3万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2004
  • 项目状态:
    已结题

项目摘要

[Background and Purpose]Polypoidal choroidal vasculopathy(PCV) is characterized by branching choroidal vessels with polyp-like terminal aneurismal dilations. Clinically, the vascular abnormality appears to be in the inner choroid and is composed of 2 basic elements : a polypoidal vessel and a branching vascular network. Although PCV is known to have a predilection for Asian populations, the exact pathology of it remains unclear and there are no current treatment guidelines. In this study, we aimed to evaluate choroidal vasculature and find efficient treatments for patients win PCV.[Results]1.Choroidal vessels in PCV(1)Branching vascular networkWe reported that in PCV the choroidal vasculature is altered with time, in that some vessels in the inner choroid and even the choriocapillaris may close and collateral vessels and/or new vessels may develop to form the branching vascular network. (Graefe's Archive for Clinical and Experimental Ophthalmology, 242:962-5,2004)(2)Pulsatile blood flowWe reviewed our series of cases of PCV with pulsatile polypoidal vessels and evaluated the features of such vessels in PCV. It is a unique and important characteristic that has not been reported with any other chorio-retinal diseases. (Ophthalmology, in press)2.Effect of Injection of triamcinolone acetonide(TA) for exudative age related macular degeneration/PCVWe evaluated the effect of intravitreal/sub-Tenon TA with exudative age related macular degeneration(AMD)/PCV. Intravitreal TA provided short-term improvement in visual acuity and fundus findings in exudative AMD without significant side effects such as intraocular pressure increase and endophthalmitis. (Ophthalmologica, in press)Trans-Tenon's retrobulbar TA injection may be a potential option for treating PCV from the point of view of effectiveness, safety, and cost. (Graefe's Archive for Clinical and Experimental Ophthalmology, in press)
【背景与目的】息肉状脉络膜血管病变(polypoidalchoroidalvasculopathy,PCV)是以脉络膜血管分支和息肉样终末血管扩张为特征的一种疾病。临床上,血管异常似乎是在脉络膜内部,并由2个基本要素组成:息肉状血管和分支血管网。虽然已知PCV对亚洲人群有偏好,但其确切的病理学尚不清楚,目前也没有治疗指南。在这项研究中,我们的目的是评估脉络膜血管,并找到有效的治疗方法,为患者赢得PCV。[结果] 1. PCV脉络膜血管(1)分支血管网我们报道PCV脉络膜血管系统随时间的变化,在脉络膜内部甚至脉络膜毛细血管中的一些血管可能关闭,并产生侧支血管和/或新生血管,形成分支血管网。(Graefe 'sArchiveforClinicalandExperimentalOphthalmology,242:962- 5,2004)(2)搏动性血流我们回顾了我们的一系列PCV伴搏动性息肉样血管的病例,并评价了PCV中这些血管的特征。这是一个独特的和重要的特点,尚未报告与任何其他脉络膜视网膜疾病。2.曲安奈德(TA)注射治疗渗出型老年性黄斑变性(AMD)/PCV的疗效观察我们评价了玻璃体内/Tenon下TA治疗渗出型AMD/PCV的疗效。玻璃体内TA可在短期内改善渗出性AMD患者的视力和眼底表现,而无明显副作用,如眼内压升高和眼内炎。(Ophthalmologica,出版中)从有效性、安全性和成本的角度来看,经眼球后TA注射可能是治疗PCV的潜在选择。(Graefe's Archive for Clinical and Experimental Ophthalmology,出版中)

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pulsatile blood flow in the poloypoidal choroidal vasculopathy
息肉状脉络膜血管病变中的搏动血流
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Okubo A;Ito M;Sameshima M;Uemura A;Sakamoto T
  • 通讯作者:
    Sakamoto T
Intravitreal triamcinolone acetonide for exudative age related macular degeneration of Japanese patients
玻璃体内注射曲安奈德治疗日本患者渗出性年龄相关性黄斑变性
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ito M;Okubo A;Sonoda Y et al.
  • 通讯作者:
    Sonoda Y et al.
Pulsatile blood flow in the polypoidal choroidal vasculopathy
  • DOI:
    10.1016/j.ophtha.2005.03.017
  • 发表时间:
    2005-08-01
  • 期刊:
  • 影响因子:
    13.7
  • 作者:
    Okubo, A;Ito, M;Sakamoto, T
  • 通讯作者:
    Sakamoto, T
ポリープ状脈絡膜血管症の病理
息肉状脉络膜血管病的病理学
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kosaka M;Sun G;Haruta M;Takahashi M.;大久保 明子他
  • 通讯作者:
    大久保 明子他
Okubo A, Sameshima M, Sakamoto T: "Plasticity of polypoidal lesions in polypoidal choroidal vasculopathy"Graefe's Archive for Clinical and Experimental Ophthalmology. (in press).
Okubo A、Sameshima M、Sakamoto T:“息肉样脉络膜血管病变中息肉样病变的可塑性”Graefe 临床和实验眼科档案。
  • DOI:
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  • 期刊:
  • 影响因子:
    0
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OKUBO Akiko其他文献

OKUBO Akiko的其他文献

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{{ truncateString('OKUBO Akiko', 18)}}的其他基金

The role of sunlight exposure, humoral factors, and arteriosclerosis in age-related macular degeneration
阳光照射、体液因素和动脉硬化在年龄相关性黄斑变性中的作用
  • 批准号:
    19592028
  • 财政年份:
    2007
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Pathogenesis of polypoidal choroidal vasculopathy focusing on the extracellular matrix
息肉状脉络膜血管病变的发病机制聚焦于细胞外基质
  • 批准号:
    17591844
  • 财政年份:
    2005
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Regeneration of choroidal vessel using human induced pluripotent stem cell derived retinal pigment epithelium
使用人诱导多能干细胞来源的视网膜色素上皮再生脉络膜血管
  • 批准号:
    17K11498
  • 财政年份:
    2017
  • 资助金额:
    $ 2.3万
  • 项目类别:
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CHOROIDAL VESSEL DESTRUCTION TO TREAT OCULAR MELANOMA
脉络膜血管破坏治疗眼部黑色素瘤
  • 批准号:
    3187499
  • 财政年份:
    1987
  • 资助金额:
    $ 2.3万
  • 项目类别:
CHOROIDAL VESSEL DESTRUCTION TO TREAT OCULAR MELANOMA
脉络膜血管破坏治疗眼部黑色素瘤
  • 批准号:
    3187500
  • 财政年份:
    1987
  • 资助金额:
    $ 2.3万
  • 项目类别:
CHOROIDAL VESSEL DESTRUCTION TO TREAT OCULAR MELANOMA
脉络膜血管破坏治疗眼部黑色素瘤
  • 批准号:
    3187498
  • 财政年份:
    1987
  • 资助金额:
    $ 2.3万
  • 项目类别:
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