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Volumetric MR Imaging of Head and Neck Cancer: Correlation between Tumor Volume and Survival.

头颈癌的体积 MR 成像：肿瘤体积与生存率之间的相关性。

基本信息

批准号：
17591969
负责人：
KIMURA Yasuo
金额：
$ 2.18万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

The size of the primary lesion and the lymph node metastasis are critical indicators for the patient prognosis. Here we sought to assess the correlation between these two prognostic parameters in patients with pharyngeal or oral cancer. We studied 66 patients with oral (n = 42) or pharyngeal (n = 24) cancer. Of these patients, 26 (10 with oral and 15 with pharyngeal carcers) were associated with lymph node metastases. We measured the volumes of the primary lesions as gadolinium-enhanced areas on T1-weighted images and as hyperintense areas on fat-suppressed (STIR) T2-weighted images. Histologically confirmed metastatic nodes were correlated with those on fat-suppressed T2-weighted MR images. The volume measurements by the two MR imaging sequences yielded similar results. The tumor volumes were well correlated with the T category for the primary lesion both in oral and pharyngeal cancers. The volumes of the oropharhngeal and hypopharyngeal cancers were significantly greater in patients with metastatic nodes than in patients without metastasis, whereas there was no significant correlation between the tumor volume and nodal metastasis in patients with oral cancer. Furthermore, the tumor volume significantly influenced the lymph node distribution in the neck of patients with pharyngeal cancer, but not in those with oral cancer. The tumor volume was a good indicator for the possible nodal metastasis in the neck of patients with oropharngeal or hypopharyngeal cancer, but not in those with oral cancer.

原发灶的大小和淋巴结转移是影响患者预后的重要指标。在这里，我们试图评估这两个预后参数之间的相关性在咽或口腔癌患者。我们研究了66例口腔癌（n = 42）或咽癌（n = 24）患者。在这些患者中，26例（10例口腔癌和15例咽癌）与淋巴结转移有关。我们测量了原发病灶的体积，在T1加权像上表现为钆增强区，在脂肪抑制（STIR）T2加权像上表现为高信号区。组织学证实的转移性淋巴结与脂肪抑制的T2加权MR图像相关。两种MR成像序列的体积测量结果相似。口腔癌和咽癌的肿瘤体积与原发灶的T分类有很好的相关性。口腔癌和下咽癌的体积在有淋巴结转移的患者中显著大于无淋巴结转移的患者，而在口腔癌患者中肿瘤体积与淋巴结转移之间没有显著相关性。此外，肿瘤体积对咽癌患者颈部淋巴结分布有显著影响，但对口腔癌患者颈部淋巴结分布无显著影响。肿瘤体积是一个很好的指标，可能在颈部淋巴结转移的口腔癌或下咽癌，但不是在那些口腔癌。