Synthesis of conjugated polyynes by alkyne metathesis

炔复分解法合成共轭多炔

• 批准号: 490938689
• 负责人: Professor Dr. Matthias Tamm
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/490938689?language=en
• 关键词: Synthesis; conjugated; polyynes; alkyne; metathesis

The synthesis of conjugated polyynes is a genuine scientific challenge nowadays. Although several methods have been reported over the last decades, diverse and efficient methods for the synthesis of compounds bearing more than two conjugated CC triple bonds remain inadequate. In this project, we propose to use alkyne metathesis as a new "soft" and expedient method for the synthesis of triynes, tetraynes, pentaynes and beyond. On the basis of promising preliminary results obtained with triynes, we proposed new catalysts that are designed to control the selectivity towards the targeted polyynes. After evaluating the scope and limitations of our methodology, it will be applied to the synthesis of polyynes that are currently inaccessible with known methods in the field of physical organic chemistry. An ultimate goal of the project is the synthesis of C24, a cyclic allotrope of carbon.

共轭多炔的合成是当今一个真正的科学挑战。虽然在过去的几十年里已经报道了几种方法，但合成具有两个以上共轭CC三键的化合物的多样化和高效的方法仍然不足。在这个项目中，我们提出使用炔复分解作为一种新的“软”和方便的方法来合成三炔、四炔、五炔等。在triynes的初步结果的基础上，我们提出了新的催化剂来控制对目标多ynes的选择性。在评估了我们的方法的范围和局限性之后，它将被应用于目前在物理有机化学领域无法用已知方法合成的多炔。该项目的最终目标是合成碳的环同素异形体C24。