Chemically triggered metal-ion signals to generate pulsed functions in supramolecular multicomponent networks

化学触发金属离子信号在超分子多组分网络中产生脉冲功能

• 批准号: 491092614
• 负责人: Professor Dr. Michael Schmittel
• 金额: --
• 依托单位: Arbeitsgruppe Organische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/491092614?language=en
• 关键词: Chemically; triggered; metal; ion; signals

Living biological systems communicate in a highly interdependent manner using chemical signals. The use of pulsed calcium ion signals is a sophisticated method to selectively trigger a wide range of cellular processes using frequency-encoded information transfer. Following the biological model, functional artificial multicomponent systems are to be operated via metal ion pulses. Here, the discrete addition of a fuel acid temporarily triggers first a release of metal ions followed by their retrieval, resulting in a pulse-like re-sorting of the metallosupramolecular structure(s) into a temporary functional unit followed by its decay. The potential of this process is to perform either catalytic reactions at high and low frequency or frequency-encoded molecular logic processes via the time modulated addition of the fuel acid. This additional dimension of steering, which is close to the dynamic regulation of biological tasks by calcium ion pulses, promises an entry into pulsed, later frequency modulated process control.

活着的生物系统使用化学信号以高度相互依存的方式进行交流。使用脉冲钙离子信号是一种复杂的方法，可以使用频率编码的信息传输来选择性地触发广泛的细胞过程。按照生物模型，功能性人工多组分系统将通过金属离子脉冲进行操作。在这里，燃料酸的离散添加暂时首先触发金属离子的释放，然后回收金属离子，导致金属超分子结构(S)脉冲式重新分类为临时功能单元，然后是其衰变。这一过程的潜力是通过燃料酸的时间调制添加来执行高频和低频的催化反应或频率编码的分子逻辑过程。这一额外的转向维度接近于钙离子脉冲对生物任务的动态调节，有望进入脉冲、后来的频率调制过程控制。