Coordination Funds

该研究单位的目标将是开发和验证一种综合解决方案，用于颌面外科中附加制造的植入物的制造、表征和基于模拟的设计，同时考虑到个体骨骼的生理条件。因此，需要一种整体的鉴定方法，以及对材料科学和工程、医学工程和数值模拟的跨学科考虑。在此基础上，为了描述机械、生物和腐蚀过程及其相互作用，多学科联盟实施了新的、基于机理的体外和体内测试方法，包括多尺度模拟和建模方法(在硅胶中)。由于目前设想的研究主题的多样性和复杂性，必须由年轻的科学家在成熟的研究人员的监督下进行跨学科的处理。所追求的科学问题的复杂性将逐步增加。在第一个资助期(FP-1：1年至4年)内，将对钛制成的永久性植入物的机械-生物行为进行表征。此外，腐蚀机制对镁制成的生物可吸收植入物的机械生物行为的影响将在第二个资助期(FP-2：第5至第8年)面临。总而言之，可以定义以下总体目标：1)通过考虑特定的骨结构和可能的骨缺陷(例如，防止骨增大)来进行患者个性化的植入物设计2)通过使用晶格结构局部调整硬度来最小化植入物-骨界面内的应力屏蔽，以实现成功的组织整合3)表征晶格结构对诸如微结构、缺陷形成和表面形态的量的影响，4)通过表面处理(如喷砂)和涂层(如PEM涂层)改变表面形态和性能，以促进组织整合5)借助人工神经元网络，通过将多个可伸缩性级别联系起来，通过多尺度方法对机械、生物和腐蚀性特性进行时间和资源高效的模拟和建模6)开发时间和资源高效的实验和模拟表征方法，以提高质量，从而提高长期存活率，并加快未来植入物的开发和鉴定周期。

Aim of the research unit will be the development and validation of an integrated solution for the manufacturing, characterization and simulation-based design of additively manufactured implants in maxillofacial surgery, taking into account physiological conditions of the individual bone situation. Therefore, a holistic qualification approach, as well as an interdisciplinary consideration of materials science and engineering, medical engineering and numeric simulation, is required. Based on this, novel and mechanism-based in vitro and in vivo testing methods, including multi-scale simulation and modeling methods (in silico), are implemented by the interdisciplinary consortium in order to describe the mechanical, biological and corrosive processes and their interactions. Due to the present diversity and complexity of the envisaged research topic, interdisciplinary processing by young scientists, supervised by proven researchers, is mandatory. The complexity of the pursued scientific issues will be increased stepwise. Within the first funding period (FP-1: 1st to 4th year) the mechanical-biological behavior of permanent implants made of titanium will be characterized. Supplementary, the effect of corrosion mechanisms on the mechanical-biological behavior of bioresorbable implants made of magnesium will be faced in the second funding period (FP-2: 5th to 8th year). In summary, the following overall objectives can be defined:1) Patient-individualized implant design by considering specific bone structures and possible bone defects (e.g. prevention of bone augmentation)2) Minimization of stress-shielding within implant-bone interface through local adjustment of stiffness by using lattice structures for a successful tissue integration3) Characterization of the influence of lattice structuring on quantities such as microstructure, defects formation and topography, and the correlation with the corresponding property profile4) Modification of surface morphology and properties through surface treatment (e.g. sandblasting) and coating (e.g. PEM coatings) in order to stimulate tissue integration5) Time- and resource-efficient simulation and modeling of the mechanical, biological and corrosive property profile via multi-scale approaches by linking multiple levels of scalability with the aid of artificial neuronal networks6) Development of a time- and resource-efficient experimental and simulation-based characterization methodology to increase the quality, consequently also the long-term survival rate and to accelerate the development and qualification period for future implants.