Coordination Funds

协调基金

• 批准号: 495857095
• 负责人: Professor Dr.-Ing. Frank Walther
• 金额: --
• 依托单位: Lehrstuhl für Werkstoffprüftechnik
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/495857095?language=en
• 关键词: Coordination; Funds

Aim of the research unit will be the development and validation of an integrated solution for the manufacturing, characterization and simulation-based design of additively manufactured implants in maxillofacial surgery, taking into account physiological conditions of the individual bone situation. Therefore, a holistic qualification approach, as well as an interdisciplinary consideration of materials science and engineering, medical engineering and numeric simulation, is required. Based on this, novel and mechanism-based in vitro and in vivo testing methods, including multi-scale simulation and modeling methods (in silico), are implemented by the interdisciplinary consortium in order to describe the mechanical, biological and corrosive processes and their interactions. Due to the present diversity and complexity of the envisaged research topic, interdisciplinary processing by young scientists, supervised by proven researchers, is mandatory. The complexity of the pursued scientific issues will be increased stepwise. Within the first funding period (FP-1: 1st to 4th year) the mechanical-biological behavior of permanent implants made of titanium will be characterized. Supplementary, the effect of corrosion mechanisms on the mechanical-biological behavior of bioresorbable implants made of magnesium will be faced in the second funding period (FP-2: 5th to 8th year). In summary, the following overall objectives can be defined:1) Patient-individualized implant design by considering specific bone structures and possible bone defects (e.g. prevention of bone augmentation)2) Minimization of stress-shielding within implant-bone interface through local adjustment of stiffness by using lattice structures for a successful tissue integration3) Characterization of the influence of lattice structuring on quantities such as microstructure, defects formation and topography, and the correlation with the corresponding property profile4) Modification of surface morphology and properties through surface treatment (e.g. sandblasting) and coating (e.g. PEM coatings) in order to stimulate tissue integration5) Time- and resource-efficient simulation and modeling of the mechanical, biological and corrosive property profile via multi-scale approaches by linking multiple levels of scalability with the aid of artificial neuronal networks6) Development of a time- and resource-efficient experimental and simulation-based characterization methodology to increase the quality, consequently also the long-term survival rate and to accelerate the development and qualification period for future implants.

该研究单位的目标是开发和验证一种集成解决方案，用于制造、表征和基于模拟的颌面外科增材制造植入物的设计，同时考虑到个体骨骼状况的生理条件。因此，需要一个全面的资格认证方法，以及材料科学与工程、医学工程和数值模拟的跨学科考虑。基于此，跨学科联盟实施了新的基于机制的体外和体内测试方法，包括多尺度模拟和建模方法（计算机），以描述机械，生物和腐蚀过程及其相互作用。由于目前设想的研究课题的多样性和复杂性，年轻科学家在经过验证的研究人员的监督下进行跨学科处理是强制性的。所追求的科学问题的复杂性将逐步增加。在第一个资助期内（FP-1：第1至第4年），将对钛制成的永久植入物的机械生物学行为进行表征。此外，腐蚀机制对镁生物可吸收植入物力学生物学行为的影响将在第二个资助期（FP-2：第5至第8年）进行研究。总之，可以定义以下总体目标：1)通过考虑特定骨结构和可能的骨缺陷（例如，防止骨增强）来设计患者个性化的种植体；2)通过使用晶格结构进行成功的组织整合，通过局部调整刚度来最小化种植体-骨界面内的应力屏蔽；3)表征晶格结构对微观结构等数量的影响；4)通过表面处理（如喷砂）和涂层（如PEM涂层）来改变表面形貌和性能，以促进组织整合。5)时间和资源效率高的机械仿真和建模。在人工神经网络的帮助下，通过多尺度方法连接多个可扩展性水平，通过多尺度方法来描述生物和腐蚀特性。6)开发一种时间和资源效率高的实验和基于模拟的表征方法，以提高质量，从而提高长期存活率，并加快未来植入物的开发和鉴定周期。