Self Renew and Cell Differentiation in Hemopoietic System

造血系统的自我更新和细胞分化

• 批准号: 10181103
• 负责人: SUDA Toshio
• 金额: $ 88.58万
• 依托单位: Keio University (2002)Kumamoto University (1998-2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10181103/
• 关键词: Hematopoietic Stem Cell; Stemness; Cell differentiation; Signal transductiom; Transcriptional regulation; Gene transfer; Abstract; Home page; 自己複製; 再生医学研究; 細胞接着; 相互変換; 間葉系幹細胞; 多分化能; 幹細胞; シグナル; 転写; クロストーク; HIVベクター; ES細胞; 造血システム; 血管新生 /

In 2002, I worked up and published the achievement of the studies on hematopoietic system, which was supported by Grant-in-Aid for Scientific Research on Priority Areas (1). Booklets consisted of about 300 pages, which described the summary of purpose and results of this collaborative studies, and were distributed to each investigators and to the concerned institutions. And the achievement can be accessed by internet in the home page of the Ministry of Education, Sports and Culture (http://www.mext. go.jp/a_menu/shikou/hojyo/) and Keio University, School of Medicine (http:/web.sc.itc.keio.ac.jp/celldiff). This study, especially on the interaction between hematopoietic stem cells and vscular endothelial cells was evaluated excellent by the final review. This study supported by Grant-in-Aid for Scientific Research on Priority Areas (1) was easily evaluated by peer review. As results, the research was facilitated by the discussion among experts in this area. In 2003, based on this hematopoietic stem cell study, the stem cell study will develop by the spport of Grant-in-Aid for Scientific Research on Priority Areas ("Stem Cell")

2002年，我完成并发表了造血系统研究成果，该成果得到了优先领域科学研究资助金（1）的支持。小册子约300页，概述了这项合作研究的目的和结果，并分发给每一位研究人员和有关机构。这一成果可通过教育、体育和文化部的主页（http：//www.mext. go.jp/a_menu/shikou/hojyo/）和庆应义塾大学医学院（http：/web.sc.itc.keio.ac.jp/celldiff）。本研究，尤其是造血干细胞与血管内皮细胞相互作用的研究，最终评价为优秀。这项研究得到了优先领域科学研究补助金（1）的支持，很容易通过同行评审进行评价。因此，该领域专家之间的讨论促进了研究。2003年，在造血干细胞研究的基础上，将通过优先领域科学研究补助金（“干细胞”）的支持开展干细胞研究。

项目成果

Hamaguchi I: "In vitro hematopoietic and endothelial cell development from cells expressing TEK receptors in murine aorta-gonad-mesonephros region"Blood. 93. 1549-1556 (1999)

Hamaguchi I：“在小鼠主动脉-性腺-中肾区域表达 TEK 受体的细胞的体外造血和内皮细胞发育”血液。

Takakura N: "A role for hematopoietic cells in promoting angiogenesis."Cell. 102. 199-209 (2000)

Takakura N：“造血细胞在促进血管生成中的作用。”细胞。

Arai F: "Mesenchymal stem cells in perichondrium express activated cell adhesion molecule and participate in bone formation"J. Exp. Med. 195. 1449-1563 (2002)

Arai F：“软骨膜中的间充质干细胞表达活化的细胞粘附分子并参与骨形成”J。

Morii E: "Inhibitory effect of MITF encoded by the mutant mi allele on GABP-mediated transcript expression in mouse mast cells"Blood. 97. 3032-3039 (2001)

Morii E：“突变mi等位基因编码的MITF对小鼠肥大细胞中GABP介导的转录物表达的抑制作用”血液。

Kashii, Y: "A member of forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction"Blood. 96. 941-949 (2000)

Kashii, Y：“叉头家族转录因子 FKHRL1 的成员，是促红细胞生成素信号转导中磷脂酰肌醇 3-激酶-Akt 激活途径的下游分子之一”。