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Adaptive design of the microbrain system : project achievements and perspectives

微脑系统的自适应设计：项目成果和前景

基本信息

批准号：
10187101
负责人：
TAKAHATA Masakazu
金额：
$ 31.87万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2002
项目状态：
已结题

项目摘要

Physiological mechanisms underlying behavioral functions of the arthropod microbrain system have been investigated in terms of species specificity and generality in the project "Adaptive design of the microbrain system" carried out from 1998 to 2001. The project yielded a number of new findings including the structure and function of the mushroom body, central projections and processing of the insect olfactory system, synaptic mechanisms of the central compensation process following partial ablation of mechanosensory organs, and molecular and developmental knowledge on the microbrain cytoarchitecture. In addition to propulsion of individual research, development of new experimental and theoretical tools for the microbrain research, including molecular biological techniques, small-scale electronic IC devices and neuro-informatics theory, has been fully backed up in this project. Through these results as well as many others obtained in experimental and computational approaches to the microbrain system, the current project emphasized practical advantages of the arthropod brain as a small system in scientific researches in which molecular, cellular and neuronal circuit structures and functions are to be understood in direct relation to the behavior of an individual animal in natural conditions. During the substantial period of research over 3 years (1999-2001), about 50 researches was enrolled in this project as chief researchers, domestic and international symposia and meetings were held 14 times, and workshops were conducted in 6 places throughout the country. The results have been published as more than 200 research articles in scientific journals.

1998年至2001年开展的“微脑系统的自适应设计”项目从物种特异性和普遍性的角度研究了节肢动物微脑系统行为功能的生理机制。该项目产生了一些新的发现，包括蘑菇体的结构和功能，昆虫嗅觉系统的中央投射和处理，机械感觉器官部分消融后中央补偿过程的突触机制，以及关于微脑细胞结构的分子和发育知识。除了个人研究的推进，开发新的实验和理论工具，包括分子生物学技术，小规模电子IC器件和神经信息学理论，在这个项目中得到了充分的支持。通过这些结果以及在实验和计算方法中获得的许多其他结果，当前的项目强调了节肢动物大脑作为科学研究中的小系统的实际优势，其中分子，细胞和神经元电路结构和功能与自然条件下单个动物的行为直接相关。在3年多的实质性研究期间（1999-2001年），约有50名研究人员作为首席研究员参加了该项目，举办了14次国内外研讨会和会议，并在全国6个地方举办了讲习班。研究结果已在科学期刊上发表了200多篇研究文章。