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Advanced Brain Science Project

高级脑科学项目

基本信息

批准号：
12209001
负责人：
IHARA Yasuo
金额：
$ 997.25万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12209001/
关键词：
Neurogenesis Guidance molecules BDNF and visual center Alzheimer's disease Spinal and bulbar muscular atrophy Polyglutamine diseases Higher cortical function Plasticity of the neuron 脳の発生・発達アルツハイマー病神経変性疾患神経可塑性システム回路とモデル神経軸索伸

项目摘要

By this project, many papers with the highest impact have been published, which have clearly shown that the level of neuroscience in Japan is very high. When the project was initiated in 2000, goals were set for each field, and I believe all of us have reached them. Among the excellent publications, the following ones are exceptional: "Brain repair" by Dr. M. Nakafuku; identification of guidance molecules by Dr. K. Kaibuchi, discovery of neprilysin as a AB-degrading protease by Dr. T. Saido, and clinical trial of a new drug for X-linked spinal and bulbar muscular atrophy by Dr. G. Sobue. In addition, steady progress in the research of higher cortical function using monkey by Dr. J. Tanji should be mentioned here. Finally, identification of one susceptibility gene for Alzheimer's disease is a milestone in this kind of research in Japan.It is often claimed that interdisciplinary interaction is required to significantly advance science, and indeed this project provided such opportunity. This can partly explain why A01 investigators have obtained the most striking data: excellent investigators majoring development in general, neurobiology and stem cells have got together under the flag of neurogenesis, and heavily interacted with each another.

通过该项目，发表了许多具有最高影响力的论文，这些论文清楚地表明日本的神经科学水平非常高。当这个项目在2000年启动时，为每个领域设定了目标，我相信我们所有人都达到了目标。在优秀的出版物中，以下是例外：M.导向分子的鉴定。Kaibuchi博士发现脑啡肽酶是一种AB降解蛋白酶。Saido博士和G.索布江此外，在此应提及J.Tanji博士使用猴子进行的高级皮质功能研究的稳步进展。最后，阿尔茨海默病易感基因的确定是日本这类研究的里程碑。人们常说，要想使科学取得重大进展，就需要跨学科的相互作用，而这一项目确实提供了这样的机会。这可以部分解释为什么A01研究人员获得了最惊人的数据：一般发育、神经生物学和干细胞专业的优秀研究人员在神经发生的旗帜下聚集在一起，并相互作用。