Advanced Brain Science Project

通过这个项目，发表了许多具有最高影响力的论文，这清楚地表明了日本神经科学的水平是非常高的。当这个项目在2000年启动时，为每个领域设定了目标，我相信我们所有人都达到了目标。在这些优秀的出版物中，以下几个是例外的：M. Nakafuku博士的“大脑修复”；K. Kaibuchi博士鉴定了引导分子，T. Saido博士发现了neprilysin是一种降解ab的蛋白酶，G. Sobue博士对一种治疗x连锁脊髓和球性肌萎缩症的新药进行了临床试验。此外，在此还应提及J. Tanji博士在猴子高级皮质功能研究方面取得的稳步进展。最后，一个阿尔茨海默病易感基因的鉴定是日本这类研究的一个里程碑。人们常说，跨学科的互动是推动科学进步的必要条件，而这个项目确实提供了这样的机会。这在一定程度上解释了为什么A01研究者获得了最惊人的数据：在神经发生的旗帜下，研究一般发育、神经生物学和干细胞的优秀研究者聚集在一起，相互之间产生了大量的互动。

By this project, many papers with the highest impact have been published, which have clearly shown that the level of neuroscience in Japan is very high. When the project was initiated in 2000, goals were set for each field, and I believe all of us have reached them. Among the excellent publications, the following ones are exceptional: "Brain repair" by Dr. M. Nakafuku; identification of guidance molecules by Dr. K. Kaibuchi, discovery of neprilysin as a AB-degrading protease by Dr. T. Saido, and clinical trial of a new drug for X-linked spinal and bulbar muscular atrophy by Dr. G. Sobue. In addition, steady progress in the research of higher cortical function using monkey by Dr. J. Tanji should be mentioned here. Finally, identification of one susceptibility gene for Alzheimer's disease is a milestone in this kind of research in Japan.It is often claimed that interdisciplinary interaction is required to significantly advance science, and indeed this project provided such opportunity. This can partly explain why A01 investigators have obtained the most striking data: excellent investigators majoring development in general, neurobiology and stem cells have got together under the flag of neurogenesis, and heavily interacted with each another.