DEVELOPMENT OF MICRO FRUID CONTROL SYSTEM BY USING MICROSTEREOLITHOGRAPHY

利用微立体光刻技术开发微流体控制系统

• 批准号: 13124205
• 负责人: IKUTA Koji
• 金额: $ 30.21万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13124205/
• 关键词: Biochemical IC; Micro Stereolithography; MEMS; Two-Photon Stereolithography; Tailor-made Medicine; Implantable Micro Device; Biodegradable Polymer; Optically Driven Micromachine; 2光子高速光造形法; 光硬化性樹脂; 生体適合性材料; テーラーメード製薬; 体内埋込型デバイス; マイクロポンプ; マイク

Biochemical IC chips for future micro/nano chemical device have been investigated. We took a systematic research approach for development compared with conventional research project.1) New fabrication process to create real three-dimensional micro/nano structures has been developed. The micro/nano stereo lithography process originally developed in lkuta's laboratory was further advanced for this project. Nano scale needle and tweezers were fabricated and driven by laser trapping. Smooth remote drive and ft Newton scale force sensing were demonstrated experimentally.2) New chip-sets of biochemical IC chips have been successfully developed and their functions were verified. Cell-free protein synthesis with advanced micro pump chips was succeeded. Several proteins have been synthesized from DNA without any living cell. This function is the key technology for not only post genome research but also order-made medicine based.3) Homogenizer chips to destroy cell and tissue in micro scale without damaging cell protein. Simple and effective coupling method between biochemical IC chips was developed. The silicon-rubber coupling can make a tight sealing. These results directly contribute to real total micro analysis process and devices.4) Artificial kidney device utilizing micro stereo lithography has been developed. Miniaturization and rat test were carried out successfully in Prof. Nagakura's lab.5) New technique for cell biology by using micro fluidics has been proposed and verified by Prof. Sokabe and Prof. Naruse. Since many new knowledge in life science were obtained through the new approach, it was made clear that micro chemical devices such as biochemical IC chips can contribute to basic life science as well as biomedical applications.

研究了用于未来微纳化学器件的生化集成电路芯片。与传统的研究项目相比，我们采取了系统的研究方法进行开发。1）开发了新的制造工艺，以创建真实的三维微/纳米结构。最初在lkuta实验室开发的微/纳米立体光刻工艺在这个项目中得到了进一步的发展。制作了纳米级的针和镊子，并利用激光捕获驱动。实验验证了遥控驱动的平稳性和牛顿尺度力传感的可靠性。2）研制成功新型生化IC芯片组，并验证了其功能。利用先进的微泵芯片成功实现了无细胞蛋白质合成。有几种蛋白质是在没有任何活细胞的情况下由DNA合成的。这一功能不仅是后基因组研究的关键技术，也是订单医学的关键技术。3）匀浆器芯片，在微尺度上破坏细胞和组织，而不破坏细胞蛋白。提出了一种简单有效的生化IC芯片间的耦合方法。采用硅橡胶联轴器，密封严密。这些结果直接有助于真实的全微分析过程和装置。4）利用微立体光刻技术研制了人工肾装置。在长仓教授的实验室成功地进行了小型化和大鼠试验。5）由Sokabe教授和Naruse教授提出并验证了使用微流体的细胞生物学新技术。由于生命科学中的许多新知识都是通过这种新方法获得的，因此可以清楚地看到，生物化学IC芯片等微化学器件可以为基础生命科学和生物医学应用做出贡献。

项目成果

S. Maruo, K. Ikuta: "Submicron stereolithography for the production of freely movable mechanisms by using single-photon polymerization"Sensors and Actuators A. 96(In press). (2002)

S. Maruo、K. Ikuta：“利用单光子聚合生产可自由移动机构的亚微米立体光刻技术”传感器和执行器 A. 96（正在出版）。

Shoji Maruo, Koji Ikuta, Hayato Korogi: "Force-Controllable, Optically Driven Micromachines Fabricated by Single-Step Two-Photon Microstereolithography"Journal of Microelectromechanical Systems. 12・5. 533-539 (2003)

Shoji Maruo、Koji Ikuta、Hayato Korogi：“通过单步双光子微立体光刻技术制造的力可控光学驱动微型机器”《微机电系统杂志》12・5（2003 年）。

Shoji Maruo, Koji Ikuta, Hayato Korogi: "Optically Driven A4icromanipulation Tools Fabricated by Two-photon Microstereolithography"Three-dimensional Nanoengineerd Assemblies, Mat.Res.Soc.. 739. 269-274 (2002)

Shoji Maruo、Koji Ikuta、Hayato Korogi：“通过双光子微立体光刻技术制造的光学驱动 A4 微操作工具”三维纳米工程组件，Mat.Res.Soc.. 739. 269-274 (2002)

Koji Ikuta, Hironobu Ichikawa, Katsuya Suzuki, Takahiro Yamamoto: "Safety Active Catheter with Multiple-segments Driven by Innovative Hydro-Pressure Micro Actuators"Proc.of the 16th Annual International Conference on Micro Electro Mechanical Systems. 130-

Koji Ikuta、Hironobu Ichikawa、Katsuya Suzuki、Takahiro Yamamoto：“创新型液压微执行器驱动的多段安全主动导管”第 16 届微机电系统国际会议议程。

Makoto Nokata, Koji Ikuta, Hideki Ishii: "Safety-Optimizing Method of Human-Care Robot Design and Control"Proc.of IEEE International Conference on Robotics and Automation (ICRA'02). 1991-1996 (2002)

Makoto Nokata、Koji Ikuta、Hideki Ishii：“人类护理机器人设计与控制的安全优化方法”Proc.of IEEE 国际机器人与自动化会议 (ICRA02)。