Downsizing studies on chemical experiments for minimization of environmental loads

考虑到环境、健康和安全废物管理问题的现状，减少大学实验室化学实验中的实验废物的学术教育活动作为本项目或优先领域项目的科学研究的标题是合适的。研究结果表明，“化学实验的小型化”是该项目研究活动的关键词，微型液相色谱系统集成了微型色谱柱，以减少有害有机溶剂。研制了一种用于空气中痕量气体监测的微芯片装置。为实现高灵敏度的大气NO_2气体测量，对微型装置进行了研制和优化。在风洞中的检测限约为1 ppb。微量气体测量微芯片由两个聚甲基丙烯酸甲酯 ...更多信息 e板和聚四氟乙烯过滤器作为吸收区。微通道采用注射成型法制备。在优化的条件下，对该微芯片器件进行了NO_2的测定。与协定所示常规文书生成的日期进行比较。本计画也进行了有机合成微型反应器之开发。建立了柴油机排气颗粒物中苯并[a]芘（BaP）和苯并[k]荧蒽（BkF）的同时测定装置和净化芯片预处理装置。该净化芯片对柴油机尾气颗粒物溶液中BaP和BkF的回收率达到90%以上。将净化芯片与检测装置相结合，检测时间较传统方法缩短不到十分之一。将柴油机尾气颗粒物（DEP）中的多环芳烃固定在硅胶微球中，装入微芯片中，用氯仿萃取。开发了微芯片反应器预处理系统，用于洗脱DEP中的多环芳烃。这些化学实验结果与常规的体尺度实验结果一致。少

Academic educational activities for decresing experimental wastes on chemical experiments in university laboratories were proper as the title of this program or the scientific research of priority area project, considering the present situations of the environmental, health and safety waste management issues. It was concluded that the research activities would give their suggestion about the new term to the project, considering "downsizing on chemical experiments" to be the key word of the research activities of the important academic research program.Microcolumns were integrated into the micro HPLC systems to reduce hazardous organic solvents. A microchip device for monitoring of the trace gas in the air was developed. The micro device has been developed and optimized in order to measure for atmospheric nitrogen dioxide (NO_2) with high sensitivity. The detection limit was approximately 1 ppb in wind tunnel. The trace gas measurement microchip was composed of two polymethylmethacrylat … More e plates and polytetrafluoroethylene filter as absorbing area. Microchannel was fabricated by injection molding. Under optimized conditions, the microchip-device was tested measurement of NO_2. Comparison with the date generated by the conventional instrument indicated with agreements. Development of a micro reactor for organic synthesis was also carried out in this program. We developed a device for simultaneous determination of benz[a]pyrene (BaP) and benzo[k]fluoranthene (BkF) in diesel exhaust particles and clean-up microchip for pretreatment. About more than 90% of recovery of BaP and BkF in diesel exhaust particle solutions was attained by the clean-up microchip. Combining the clean-up microchip and detection device, detection time could be shortened less than one tenth compared with the conventional method. PAHs in diesel exhaust particle (DEP) were trapped into silica gel beads, which were packed into the microchip, and extracted into chloroform. Pre-treatment system with a microchip reactor was developed for eluting PAHs from DEP. These chemical experimental results with micro scale tools obtained were the same as ordinary bulk scale methods. Less