Adipomics ; Analysis of the physiological and pathological function of adipocyte

本研究的目的是阐明脂肪细胞和脂肪组织的功能，从临床上观察到许多生活方式相关疾病是由内脏脂肪的积累引发的，以及科学发现各种脂肪细胞衍生因子的异常是内脏肥胖相关疾病的共同基础，从而建立有效的策略来对抗糖尿病、动脉粥样硬化性血管疾病和某些与肥胖相关的LYFE相关疾病。从活体脂肪组织的三维分析来看，脂肪生成和血管生成的协调在肥胖脂肪组织的分化中起着至关重要的作用。脂肪组织中可见单核细胞卷曲和附着，类似于动脉粥样硬化早期的血管改变。被招募的巨噬细胞产生各种炎性细胞因子并影响脂肪细胞因子的产生，这被概念化为脂肪炎…。更多的苏改建。局部氧化应激和低氧的产生也被证明是脂肪细胞功能失调的可能机制。脂肪细胞的脂质体，即来自脂肪细胞的大泡结构，被解释为负责某种脂肪细胞因子分泌的机制。一些类型的体积感觉通道被认为是脂肪细胞增大的感受器，并部分地与肿瘤坏死因子α引起的葡萄糖摄取障碍有关。水通道蛋白7是水通道家族中的一个成员，是脂肪细胞中的一种甘油通道，其在体内的意义被证明为该分子的缺乏会导致严重的饥饿低血糖。研究表明，脂肪细胞来源的防御分子脂联素的意义，以及脂联素缺乏，低脂联素血症(通常和临床上观察到的内脏脂肪堆积)在代谢综合征的疾病发展中起着重要作用。脂联素可能的受体AdipoR1和R2的鉴定以及对缺乏这些分子的小鼠的精确分析证实了脂联素在活体中的重要性。我们相信，本项目所进行的研究确实为建立一个新的研究领域--脂肪组学--做出了贡献，这是对抗LYFE相关疾病，特别是爆炸性流行的心血管疾病所必需的

The aim of this research field is to clarify the functions of adipocyte and adipose tissue to establish an effective strategy for combating lyfe-style-related disorders such as diabetes, atherosclerotic vascular diseases and some types of cancers related to obesity from the clinical observations that many life-style-related disorders are triggered by the accumulation of visceral fat and scientific findings that abnormalities of various adipocyte-derived factors conceptualized as adipocytokines reside a common basis of visceral obesity-related disorders.From three-dimensional analyses of living adipose tissue, coordination of adipogenesis and angiogenesis plays an essential role in the differentiation of adipose tissue in obesity. Rolling and attachment of monocytes were observed in adipose tissue resembling early atherosclerotic vascular changes. Recruited macrophages produced various inflammatory cytokines and affected adipocytokines production, which was conceptualized as adipose tis … More sue remodeling. Local production of oxidative stress and hypoxia also were also proved as underlying possible mechanisms of adipocutokine dysregulation.Adiposome, macrovesicular structure from adipocyte was elucidated as machinery responsible for some kind of adipocytokine secretion. Some types of volume sensing channel were identified as a sensor of adipocyte enlargement and partially responsible for TNF α-induced impairment of glucose uptake. Aquaporin 7, a member of water channel family, was identified as a glycerol channel in adipocyte, and its significance in the body was proved by the fact that the deficiency of this molecule caused profound hypoglycemia in starvation.Vast researches revealed the significance of adiponectin, a defensive molecule derived from adipocyte, and deficiency of adiponectin, hypoadiponectinemia, (which is usually and clinically observed in visceral fat accumulation) plays important roles in the development of disorders in the metabolic syndrome. Idntifycation of AdipoRl and R2, which are possible receptors for adiponectin and precise analyses of mice lacking these molecules confirmed the importance of adiponectin in vivo.We believe that the researches performed in this project really contributed fundamental establishment of a new research field named 'adipomics', which must be required to fight against lyfe-style-related disorders, especially cardiovascular disease explosively prevailing the world Less