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Adipomics ; Analysis of the physiological and pathological function of adipocyte

脂肪组学；

基本信息

批准号：
15081101
负责人：
MATSUZAWA Yuji
金额：
$ 26.82万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15081101/
关键词：
Visceral adipose tissue Adipocytokine Adipocyte Gene expression Differentiation 内蔵脂肪

项目摘要

The aim of this research field is to clarify the functions of adipocyte and adipose tissue to establish an effective strategy for combating lyfe-style-related disorders such as diabetes, atherosclerotic vascular diseases and some types of cancers related to obesity from the clinical observations that many life-style-related disorders are triggered by the accumulation of visceral fat and scientific findings that abnormalities of various adipocyte-derived factors conceptualized as adipocytokines reside a common basis of visceral obesity-related disorders.From three-dimensional analyses of living adipose tissue, coordination of adipogenesis and angiogenesis plays an essential role in the differentiation of adipose tissue in obesity. Rolling and attachment of monocytes were observed in adipose tissue resembling early atherosclerotic vascular changes. Recruited macrophages produced various inflammatory cytokines and affected adipocytokines production, which was conceptualized as adipose tis … More sue remodeling. Local production of oxidative stress and hypoxia also were also proved as underlying possible mechanisms of adipocutokine dysregulation.Adiposome, macrovesicular structure from adipocyte was elucidated as machinery responsible for some kind of adipocytokine secretion. Some types of volume sensing channel were identified as a sensor of adipocyte enlargement and partially responsible for TNF α-induced impairment of glucose uptake. Aquaporin 7, a member of water channel family, was identified as a glycerol channel in adipocyte, and its significance in the body was proved by the fact that the deficiency of this molecule caused profound hypoglycemia in starvation.Vast researches revealed the significance of adiponectin, a defensive molecule derived from adipocyte, and deficiency of adiponectin, hypoadiponectinemia, (which is usually and clinically observed in visceral fat accumulation) plays important roles in the development of disorders in the metabolic syndrome. Idntifycation of AdipoRl and R2, which are possible receptors for adiponectin and precise analyses of mice lacking these molecules confirmed the importance of adiponectin in vivo.We believe that the researches performed in this project really contributed fundamental establishment of a new research field named 'adipomics', which must be required to fight against lyfe-style-related disorders, especially cardiovascular disease explosively prevailing the world Less

该研究领域的目的是阐明脂肪细胞和脂肪组织的功能，以建立一种有效的策略来对抗与Lyfe型相关的疾病，如糖尿病，动脉粥样硬化性血管疾病和某些类型的癌症与肥胖有关，从临床观察，许多生活方式相关的疾病是由内脏脂肪的积累和科学发现，从活体脂肪组织的三维分析来看，脂肪生成和血管生成的协调在肥胖症中脂肪组织的分化中起着重要作用。在脂肪组织中观察到单核细胞的滚动和附着，类似于早期动脉粥样硬化血管变化。募集的巨噬细胞产生各种炎症细胞因子，并影响脂肪细胞因子的产生，这被认为是脂肪组织的一个概念。 ...更多信息苏重塑。局部氧化应激和缺氧也被证明是脂肪细胞因子失调的潜在机制。脂肪体，脂肪细胞的大泡状结构被阐明为负责某种脂肪细胞因子分泌的机制。某些类型的体积感应通道被确定为脂肪细胞增大的传感器，并部分负责TNF α诱导的葡萄糖摄取障碍。水通道蛋白7（Aquaporin 7）是水通道家族的成员之一，是脂肪细胞中的甘油通道，其在机体中的重要性已被证明，缺乏该分子可导致饥饿时严重的低血糖;脂联素（Adiponectin）是脂肪细胞的防御性分子，大量研究揭示了脂联素缺乏、低脂联素血症、（这通常和临床上在内脏脂肪积聚中观察到）在代谢综合征中的病症的发展中起重要作用。AdipoR 1和R2是脂联素的可能受体，AdipoR 1和R2的鉴定以及对缺乏这些分子的小鼠的精确分析证实了脂联素在体内的重要性。我们相信，在本项目中进行的研究确实为一个名为“肥胖症”的新研究领域的基础性建立做出了贡献，该研究领域必须与Lyfe型相关疾病，特别是世界上爆炸性流行的心血管疾病作斗争。