Molecular pathogenesis and mechanism of vidseral obesity
内脏肥胖的分子发病机制及机制
基本信息
- 批准号:09307019
- 负责人:
- 金额:$ 24.45万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Obesity, especially accumulation of intra-abdomicl visreal fat is a common basis of the development of various life-style-related diseases including diabetes mellitus, dyslipoproteinemia, hypertension and atherosclerotic vascular diseases. In he current study, we investigted the biological functions of adipose tissue and molecular pathogenesis of obesity-related diseases. We have demonstrated that adipose tissue is not solely an energy-storing organ but also an endocrine organ producing and secreting a variety of biological substances in the circulation. Among them, hypersecretion of plasminogen activator inhibitor type 1 and heparin binding EGF-like growth factor form intra-abdominal adipose tissue were considered to affect the function and metabolism of vascular walls directly and to play roles in the development of vascular diseases.In this study, we especially focused on a novel collagen-like plasma protein, adiponectin and a member of aquaporin family, aquaporin adipose (AQPap). A … More dionectin was specifically and abundantly synthesized in adipose tissue. The protein was present in the circulation with the concentration of 5-10μg/ml. Different from thecases of PAI-1 and HB-EGF, plasma adiponectin concentrations were markedly reduced in obesity, especially in visceral obesity. When the vascular endothelium was injured in rats, adiponectin was observed in the injured vascular wall. The protein suppressed monocyte-adhesion to endothelial cells and proliferation of vascular smooth muscle cells, which are the initial changes of atherosclerotic lesion. By the analysis of adiponectin gene, we found missense mutation in subjects with coronary artery disease. These data suggest that adiponectin has potential protective activity against atherosclerotic vascular diseases and hypoadiponectin-emia found in visceral obesity may play a role in the development of atherosclerotic diseases.We investigated the function of AQPap in adipocytes. Several lenes of enidences supported that AQPap works as a glycerol channel in adipocytes; 1) AQPap exhibited glycerol permeability when it was expressed in oocytes, 2) expression of AQPap mRNA was induced by fasting in which glycerol release from the cell was activated, 3) glycerol release from the cells was reduced by mercuty ion, which inhibits the function of AQP family. Expression of AQPap was augumented and glycerol concentration in adipose tissue was increased in obese mice. In visceral fat accumulation, large amount of glycerol were drained into the liver via portal vein, may disturb glucose metabolism in liver.In conclusion, the expressions of various adipose-specific genes are altered in visceral obesity. These might contribute to the development of disorders in visceral obesity. Less
肥胖,尤其是动脉内脂肪堆积是糖尿病、血脂异常、高血压、动脉粥样硬化性血管疾病等多种生活方式相关疾病发生的共同基础。本文从脂肪组织的生物学功能和肥胖相关疾病的分子发病机制两个方面进行了综述。我们已经证明,脂肪组织不仅是一个能量储存器官,而且是一个内分泌器官,在循环中产生和分泌各种生物物质。其中,腹腔脂肪组织中纤溶酶原激活物抑制物1(plasminogen activator inhibitor type 1,PAI 1)和肝素结合的表皮生长因子样生长因子(heparin binding EGF like growth factor,EGF)的高分泌被认为直接影响血管壁的功能和代谢,在血管疾病的发生发展中起重要作用,本研究特别关注一种新的胶原样血浆蛋白脂联素(adiponectin)和水通道蛋白家族成员脂肪水通道蛋白(aquaporin adipose,AQPap)。一 ...更多信息 在脂肪组织中特异性地和大量地合成二粘连蛋白。该蛋白以5-10μg/ml的浓度存在于循环中。与派-1和HB-EGF不同,肥胖患者血浆脂联素水平明显降低,尤其是内脏型肥胖患者。当大鼠血管内皮损伤时,在损伤的血管壁中观察到脂联素。该蛋白抑制单核细胞与内皮细胞的粘附和血管平滑肌细胞的增殖,这是动脉粥样硬化病变的初始变化。通过对脂联素基因的分析,发现冠心病患者存在脂联素基因的错义突变。这些结果提示,脂联素对动脉粥样硬化性血管疾病具有潜在的保护作用,内脏型肥胖患者的低脂联素血症可能在动脉粥样硬化性疾病的发生发展中起一定作用。AQPap在卵母细胞中表达时表现出甘油渗透性; 2)禁食可诱导AQPap mRNA表达,激活细胞甘油释放; 3)汞离子可抑制细胞甘油释放,抑制AQP家族功能。肥胖小鼠脂肪组织中AQPap表达增强,甘油浓度升高。在内脏脂肪堆积时,大量甘油通过门静脉回流到肝脏,可能干扰肝脏的糖代谢。总之,内脏型肥胖中多种脂肪特异性基因的表达发生了改变。这些可能有助于内脏肥胖症的发展。少
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
H. Kuriyama, S. Yamada, I. Shimomura, T. Funahashi. Et al.: "Enhanced expression of hepatic asyl-CoA synthetase and microsomal triglyceride transfer protain mRNAs In the obese and hypertriglyceridemic rat with visceral fat accumulation"Hepatology. 27. 562
H.栗山,S.山田,I.下村,T.船桥。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T.Yoshizumi,T.Nakamura,M.Yamane,W.Islam.A.H.M.,et al.: "A standardized technique for the measurement of abdominal fat based on computed tomography" Radiology. (in press). (1999)
T.Yoshizumi、T.Nakamura、M.Yamane、W.Islam.A.H.M. 等人:“基于计算机断层扫描的腹部脂肪测量标准化技术”放射学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T.Nakamura et al.: "Importance of intra-abdominal visceral fat accumulation to coronary atherosclerosis in heterozygous familial hypercholesterolaemia" Int.J.Obes.21(7). 580-586 (1997)
T.Nakamura 等人:“杂合子家族性高胆固醇血症中腹内内脏脂肪积累对冠状动脉粥样硬化的重要性”Int.J.Obes.21(7)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Hirano K, Yamashita S, Nakagawa Y, Ohya T, Matsuura F, Tsukamoto K, Okamoto Y, Matsuyama A, Matsumoto K, Miyagawa J, Matsuzawa Y.: "Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic le
Hirano K、Yamashita S、Nakakawa Y、Ohya T、Matsuura F、Tsukamoto K、Okamoto Y、Matsuyama A、Matsumoto K、Miyakawa J、Matsuzawa Y.:“在培养的人单核细胞来源的 I 类清道夫受体 B 型中的表达
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Nakata A, Nakagawa Y, Nishida M, Nozaki S, Miyagawa J, Nakagawa T, Tamura R, Matsumoto K, Kameda-Takemura K, Yamashita S, Matsuzawa Y.: "CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human
Nakata A、Nakakawa Y、Nishida M、Nozaki S、Miyakawa J、Nakakawa T、Tamura R、Matsumoto K、Kameda-Takemura K、Yamashita S、Matsuzawa Y.:“CD36 是氧化低密度脂蛋白的一种新型受体,是
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MATSUZAWA Yuji其他文献
MATSUZAWA Yuji的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MATSUZAWA Yuji', 18)}}的其他基金
Adipomics ; Analysis of the physiological and pathological function of adipocyte
脂肪组学;
- 批准号:
15081101 - 财政年份:2003
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Discovery of adipose specific glycerol channel and its application to obesity therapy
脂肪特异性甘油通道的发现及其在肥胖治疗中的应用
- 批准号:
12557090 - 财政年份:2000
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Discovery of Novel Adipocyte-Derived Factors and Their Pathological and Physiological Roles in Humans; Adipocentric Hypothesis in Molecular Basis for the Development of Common Diseases
新型脂肪细胞衍生因子的发现及其在人类中的病理和生理作用;
- 批准号:
12307022 - 财政年份:2000
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Molecular mechanism of visceral fat syndrome, common basis of atherosclerotic diseases
内脏脂肪综合征的分子机制,动脉粥样硬化疾病的共同基础
- 批准号:
10044281 - 财政年份:1998
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Identification of adipose-specific genes and teir clinical significance
脂肪特异性基因的鉴定及其临床意义
- 批准号:
10557101 - 财政年份:1998
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of Gene Therapy for Familial Hypercholesterolemia-in vivo gene transfer to hepatocytes by HVJ-liposome-retrovirus method-
家族性高胆固醇血症基因疗法的开发-通过HVJ-脂质体-逆转录病毒方法将基因体内转移至肝细胞-
- 批准号:
08557062 - 财政年份:1996
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
International Study on Gene Abnormalities of GETP and LDL-Receptor
GETP 和 LDL 受体基因异常的国际研究
- 批准号:
08044280 - 财政年份:1996
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for international Scientific Research
Development of Therapy for Refractory Hyperlipidemia with LDL Receptor Gene Introduction by Lipofection Method
脂质转染法导入LDL受体基因治疗难治性高脂血症的进展
- 批准号:
06557059 - 财政年份:1994
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Cell-biological and molecular biological analyzes of reverse cholesterol transport as a protective system against atherosclerosis
反向胆固醇转运作为动脉粥样硬化保护系统的细胞生物学和分子生物学分析
- 批准号:
04404085 - 财政年份:1992
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Studies on the Preventive System Against Atherosclerosis Based on the Discovery of Cases With Choles-Terol Ester Transfer Protein Deficiency.
基于发现胆固醇-三醇酯转移蛋白缺陷病例的动脉粥样硬化预防系统研究。
- 批准号:
01480289 - 财政年份:1989
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
相似海外基金
Obesity, body fat distribution, and breast cancer risk: is visceral fat the culprit after menopause?
肥胖、身体脂肪分布和乳腺癌风险:内脏脂肪是绝经后的罪魁祸首吗?
- 批准号:
10586626 - 财政年份:2023
- 资助金额:
$ 24.45万 - 项目类别:
Effects of visceral fat obesity upon systemic organs
内脏脂肪肥胖对全身器官的影响
- 批准号:
23K09690 - 财政年份:2023
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Clarification of progress mechanism for Barrett's esophagus according to assessment of oral bacteria and visceral fat
根据口腔细菌和内脏脂肪的评估阐明巴雷特食管的进展机制
- 批准号:
23K10961 - 财政年份:2023
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Role of Mediobasal Hypothalamic Gliosis in Gestational Weight Gain and Gestational Visceral Fat Accretion
下丘脑内侧胶质细胞增生在妊娠期体重增加和妊娠期内脏脂肪堆积中的作用
- 批准号:
10742432 - 财政年份:2023
- 资助金额:
$ 24.45万 - 项目类别:
Fatty pancreas and diabetes mellitus: interaction with pancreas volume, liver fat, muscle fat, and visceral fat
脂肪胰腺和糖尿病:与胰腺体积、肝脏脂肪、肌肉脂肪和内脏脂肪的相互作用
- 批准号:
22K15685 - 财政年份:2022
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Analysis of pathophysiology of disorders related to visceral fat accumulation by trans-organ comparison of human transcriptome
通过跨器官比较人类转录组来分析与内脏脂肪堆积相关的疾病的病理生理学
- 批准号:
22K11760 - 财政年份:2022
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Prediction of physical function and metabolic risk by using distribution of trunk skeletal muscle and visceral fat
利用躯干骨骼肌和内脏脂肪的分布预测身体机能和代谢风险
- 批准号:
20K11602 - 财政年份:2020
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Clarification of onset mechanism for reflux esophagitis according to assessment of oral bacteria and visceral fat
根据口腔细菌和内脏脂肪评估阐明反流性食管炎的发病机制
- 批准号:
20K11511 - 财政年份:2020
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Using abdominal bioelectrical impedance to measure visceral fat area and cholesterol qualitative markers for assessing the risk of metabolic syndrome in children
利用腹部生物电阻抗测量内脏脂肪面积和胆固醇定性标志物评估儿童代谢综合征的风险
- 批准号:
20K19687 - 财政年份:2020
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The involvement of visceral fat-induced immune aging and chronic inflammation in surgical stress and the role of osteopontin
内脏脂肪诱导的免疫老化和慢性炎症在手术应激中的参与以及骨桥蛋白的作用
- 批准号:
20K08951 - 财政年份:2020
- 资助金额:
$ 24.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)