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Clarification of micro damage mechanism of skeletal muscle tissue and formulation of a constitutive model of muscle taking into account the damage

阐明骨骼肌组织的微观损伤机制并制定考虑损伤的肌肉本构模型

基本信息

批准号：
15086208
负责人：
TANAKA Eiichi
金额：
$ 19.58万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15086208/
关键词：
Skeletal Muscle Biomechanics Mechanical Properties Microstructure Constitutive Model Damage Evaluation 組織観察

项目摘要

From the viewpoint of injury prevention, it is very important to clarify and predict the criteria of micro damage and the mechanism of the decrease of the biological function and strength by the evolution of the micro damage. The motivations of this study are to construct a framework of a mechanical model which takes into account the micro damage of skeletal muscle.Firstly, we evaluated the relationship between the micro damage of muscular tissue and the change of its mechanical functions on strain injury and muscle contusion to clarify the influence of the micro damage on the mechanical properties of skeletal muscle. We also discussed the dependences of the activity of muscle and strain rate of the mechanical properties of muscle fascicle.To examine a framework of a mechanical model considering micro damage evolution of biological tissue, we constructed a constitutive model of cortical bone, which has relatively simple mechanical propeties. The developed model takes account of the strain rate dependency of the elastic modulus, anisotropies of the deformation and strengths, asymmetries of the deformation and strengths for tension, compression and shear, and the fracture caused by the accumulation of the micro damage.A mechanical model considering the difference of fatigability of motor unit was also studied. The proposed model represented a macroscopic fatigability of skeletal muscle qualitatively.We formulated a mechanical model of skeletal muscle and compared the simulation results with the corresponding experimental results of tensile and injury experiments of muscle. We adopted the framework of damage mechanics into the viscoelastic model for biological tissue proposed by Holzapfel et al. In this model, we assumed that skeletal muscle is a transverse isotropic viscoelastic material, and the micro damage also evolves tranverse isotropically. It was confirmed that the proposed model described the characteristic features of strain injury well.

从损伤预防的角度来看，阐明和预测微损伤的判据以及微损伤演变导致生物功能和强度下降的机理是非常重要的。本研究的目的是建立一个考虑骨骼肌微损伤的力学模型框架：首先，通过分析骨骼肌组织在应变性损伤和肌肉挫伤时的微损伤与力学性能变化之间的关系，阐明微损伤对骨骼肌力学性能的影响。讨论了肌束力学特性与肌肉活动度和应变率的关系，并建立了力学特性相对简单的皮质骨本构模型，以考察考虑生物组织微损伤演化的力学模型框架。该模型考虑了弹性模量的应变率依赖性，变形和强度的各向异性，拉、压、剪变形和强度的不对称性，以及微损伤累积导致的断裂，并研究了考虑电机单元疲劳性能差异的力学模型。该模型定性地反映了骨骼肌的宏观疲劳性，建立了骨骼肌的力学模型，并将模拟结果与相应的肌肉拉伸和损伤实验结果进行了比较。在Holzapfel等人提出的生物组织粘弹性模型中引入损伤力学的框架，假设骨骼肌为横观各向同性粘弹性材料，微损伤也是沿横观各向同性方向演化的。结果表明，该模型能较好地描述应变损伤的特征。

项目成果

期刊论文数量（83）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Formulation of a Constitutive Model of Skeletal Muscle Taking into Account Microstructure Damage (in Japanese)

考虑微观结构损伤的骨骼肌本构模型的制定（日语）

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Koparal TA.;Yamaguchi H.;Omae K.;Torii S.;Kitagawa Y.;M.Sato;C.Uyeda;T. Karino;Hiroshi Wada (Editor);Hiroshi Wada;J.Yamamoto;D. Ito
通讯作者：
D. Ito

骨格筋マイクロ要素の力学的特性の実験的検討

骨骼肌微量元素力学性能的实验研究