Impact of nuclear ERK 1/2 signalling in inflammation-driven cardiovascular diseases (B03)

点击翻译按钮获取中文摘要

ERK1/2 signalling has broad implications for many cardiovascular diseases. Preliminary data suggest that an autophosphorylation of ERK1/2 influences the function of antigen presenting cells and T cells. This ERK modification may help to predict/dissect the risk of heart failure and to direct ERK1/2 intervention strategies towards improved outcomes. Therefore, the project aims to understand the role of protective and maladaptive signaling of ERK1/2 in leukocytes in models of ischemic- and non-ischemic cardiomyopathies.