Impact of nuclear ERK 1/2 signalling in inflammation-driven cardiovascular diseases (B03)

核 ERK 1/2 信号传导对炎症驱动的心血管疾病的影响 (B03)

• 批准号: 499097644
• 金额: --
• 依托单位: Institut für Experimentelle Biomedizin, Lehrstuhl II
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/499097644?language=en
• 关键词: Impact; nuclear; ERK; signalling; inflammation

ERK1/2 signalling has broad implications for many cardiovascular diseases. Preliminary data suggest that an autophosphorylation of ERK1/2 influences the function of antigen presenting cells and T cells. This ERK modification may help to predict/dissect the risk of heart failure and to direct ERK1/2 intervention strategies towards improved outcomes. Therefore, the project aims to understand the role of protective and maladaptive signaling of ERK1/2 in leukocytes in models of ischemic- and non-ischemic cardiomyopathies.

ERK 1/2信号传导对许多心血管疾病具有广泛的意义。初步数据表明，ERK 1/2的自磷酸化影响抗原呈递细胞和T细胞的功能。这种ERK修饰可能有助于预测/分析心力衰竭的风险，并指导ERK 1/2干预策略改善预后。因此，该项目旨在了解缺血性和非缺血性心肌病模型中白细胞中ERK 1/2的保护性和适应不良信号传导的作用。