Molecular dynamics of nuclear pore complexes and regulation of nucleocytoplasmic protein transport
Molecular dynamics of nuclear pore complexes and regulation of nucleocytoplasmic protein transport
批准号:
16084204
负责人:
YONEDA Yoshihiro
金额:
$108.22万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2008
中文摘要
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英文摘要
細胞核の重要な構造体である核膜孔複合体に焦点を当て、その分子動態が複雑な生命現象とどのように深く関連しているのかを解析した。その結果、筋芽細胞から筋細胞への分化の過程で、核膜孔複合体構成因子の1つNUP358の発現量が分化に応じて変動し、その変動が筋分化に必須であることがわかった。また、核輸送因子importin・サブタイプ発現のスイッチングが細胞の分化・未分化決定機構に重要な役割を果たすことを、マウスES細胞を用いて明らかにした。
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Nuclear RNA export factor 7 is localized in processing bodies and neuronal mRNA granules through interactions with shuttling hnRNPs.
核 RNA 输出因子 7 通过与穿梭 hnRNP 的相互作用定位于加工体和神经元 mRNA 颗粒中。
DOI:
--
发表时间:
2008
期刊:
Nucl. Acids Res. 36
影响因子:
--
作者:
[Katahira, J., et. al.]
通讯作者:
et. al.
The role of Nup98 in a Crml-mediated nuclear export
Nup98 在 Crml 介导的核输出中的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Oka,M., Asally, M., Yasuda, Y., Yoneda,Y.]
通讯作者:
Yoneda,Y.
Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin α.
STAT3 的细胞外信号依赖性核输入由各种输入蛋白 α 介导。
DOI:
--
发表时间:
2005
期刊:
Biochem.Biophys.Res.Commun. 330
影响因子:
--
作者:
[Ushijima, R., et al.]
通讯作者:
et al.
Nuclear accumulation of importin a suppresses DNA repliation
输入蛋白a的核积累抑制DNA复制
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Mizuguchi, C., Yasuda, Y. and Yoneda, Y.]
通讯作者:
Y.
Importin alpha has multiple functionsEMBO
importin alpha 具有多种功能EMBO
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Yoneda, Y.]
通讯作者:
Y.
共 77 条
An integrative understanding of physiological processes based on the functional analysis of nuclear transport factors, importins
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批准号:24247036
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.45万
-
财政年份:2012
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负责人:YONEDA Yoshihiro
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依托单位:
RAN cycle and cellular senescence
-
批准号:23657130
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2011
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负责人:YONEDA Yoshihiro
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依托单位:
Novel functions of nuclear transport factors : stress-response mechanism of cell nucleus
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批准号:21247032
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.29万
-
财政年份:2009
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负责人:YONEDA Yoshihiro
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依托单位:
Nuclear dynamics
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批准号:16084101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$12.1万
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财政年份:2004
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负责人:YONEDA Yoshihiro
-
依托单位:
Regulation of nucleocytoplasmic protein transport and nuclear stress response
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批准号:16107004
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$66.89万
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财政年份:2004
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负责人:YONEDA Yoshihiro
-
依托单位:
Analysis of the molecular organization of nuclear pore complexes using nuclear transport factor, importin β
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批准号:12480215
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.18万
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财政年份:2000
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负责人:YONEDA Yoshihiro
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依托单位:
Analysis of neuron-specific nuclear protein transport by using CaM kinase IV as a substrate.
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批准号:10480200
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:1998
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负责人:YONEDA Yoshihiro
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依托单位:
Development of visualization technique which enables us to monitor the molecular dynamics between the nucleus and cytoplasm on real time in living cells
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批准号:08558079
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$11.65万
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财政年份:1996
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负责人:YONEDA Yoshihiro
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依托单位:
Molecular mechanism of extracellular dependent nuclear import of STAT1
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批准号:08458229
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.38万
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财政年份:1996
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负责人:YONEDA Yoshihiro
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依托单位:
Molecular communication between the nucleus and cytoplasm
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批准号:07282103
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$119.3万
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财政年份:1995
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负责人:YONEDA Yoshihiro
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依托单位:
Molecular mechanisms of protein translocation through nuclear pores
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批准号:06454677
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1994
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负责人:YONEDA Yoshihiro
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依托单位:
海外基金