Informatory expression system connecting cancer and immunity.

我们研究了干扰素、irf和Noxa等效应分子的生物学机制和作用。结果表明，这些分子参与了细胞转化、细胞凋亡诱导和转移信号通路。我们还发现了tlr信号之间的串扰通路。此外，我们还发现DAI和HMGB1、2、3在核酸介导的先天免疫应答中起重要作用。由于这些通路调节肿瘤的发生和恶化，我们的发现将在不久的将来被证明对开发新的肿瘤治疗方法有用。

We investigated biological mechanisms and role of effecter molecules, e.g. interferons, IRFs and Noxa. It revealed that these molecules are involved in transformation, apoptosis induction and metastasis signaling pathways. We also found the cross-talk pathway between TLRs signaling. Moreover, we identified DAI and HMGB1, 2, 3 are important for the nucleic-acid mediated innate immune responses. Since these pathways regulate tumorgenesis and exacerbation, our findings will be proved to be useful for the development of novel tumor therapy in near future.