Informatory expression system connecting cancer and immunity.

我们研究了生物学机制和效应分子的作用，例如干扰素，IRFs和Noxa。这些分子参与了肿瘤细胞的转化、凋亡诱导和转移等信号通路。我们还发现了TLRs信号之间的串扰通路。此外，我们确定DAI和HMGB1，2，3是重要的核酸介导的先天性免疫反应。由于这些通路调节肿瘤的发生和恶化，我们的研究结果将被证明是有用的，在不久的将来开发新的肿瘤治疗。

We investigated biological mechanisms and role of effecter molecules, e.g. interferons, IRFs and Noxa. It revealed that these molecules are involved in transformation, apoptosis induction and metastasis signaling pathways. We also found the cross-talk pathway between TLRs signaling. Moreover, we identified DAI and HMGB1, 2, 3 are important for the nucleic-acid mediated innate immune responses. Since these pathways regulate tumorgenesis and exacerbation, our findings will be proved to be useful for the development of novel tumor therapy in near future.