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How Chromosomal Aberrations Are Induced by Telomere Dysfunction

How Chromosomal Aberrations Are Induced by Telomere Dysfunction
端粒功能障碍如何诱发染色体畸变
批准号:
17013043
负责人:
ISHIKAWA Fuyuki
金额:
$230.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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项目成果

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中文摘要
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英文摘要
It is now well established that chromosomal aberrations play a major role in carcinogenesis. Yet, the precise mechanisms how aberrant chromosomes are formed remain unknown. In this study, we focused on the telomere, the terminal domain of linear chromosomes. First, we identified novel chromatin structures at telomeres, and next we examined how chromosomes would become unstable in dysfunctional telomeres.
期刊论文(164)
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会议论文
がん細胞悪性化の原動力としてのテロメア機能異常
端粒功能障碍是癌细胞恶性肿瘤的驱动力
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., Ishikawa, F., Fuyuki Ishikawa, Fuyuki Ishikawa, Fuyuki Ishikawa, 石川冬木, 石川冬木]
通讯作者: 石川冬木
A novel RPA-like mammalian complex CST.
一种新型的类似 RPA 的哺乳动物复合物 CST。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Akira Nabetani, Fuyuki Ishikawa, Akira Nabetani, Fuyuki Ishikawa, Fuyuki Ishikawa]
通讯作者: Fuyuki Ishikawa
Sheltrin telomere complex.
Sheltrin 端粒复合物。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Ishikawa, F., Fuyuki Ishikawa]
通讯作者: Fuyuki Ishikawa
Human ALT cells contain unusual single-stranded telomeric DNAs
人类 ALT 细胞含有不寻常的单链端粒 DNA
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Nabetani, A.]
通讯作者: A.
118
    Modeling and Analysis of Law and its Interpretations by Applying Requirements Engineering Principles
    • 批准号:
      24650017
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.0万
    • 财政年份:
      2012
    • 负责人:
      ISHIKAWA Fuyuki
    • 依托单位:
    Formation of facultative heterochromatin in fission yeast
    • 批准号:
      23657005
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2011
    • 负责人:
      ISHIKAWA Fuyuki
    • 依托单位:
    Telomere Functions in Cancer Development
    • 批准号:
      22220012
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $139.28万
    • 财政年份:
      2010
    • 负责人:
      ISHIKAWA Fuyuki
    • 依托单位:
    Studies on the structure and function of the nucleus in senescent cells
    • 批准号:
      20370079
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.65万
    • 财政年份:
      2008
    • 负责人:
      ISHIKAWA Fuyuki
    • 依托单位:
    海外基金