Cross talk between bone microenvironment and metastatic cancer cell

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Along with increasing of breast and prostate cancer patients, the metastases of cancer into bone has been important issues. It is, therefore, necessary to establish effective solutions for the metastases. Bone resorption and bone formation are active in bone tissues where several types of cells, including immune cells, hematopoietic cells, adipocytes and neural cells, are present. In this study, we examined cross-talk between cancer and bone tissues at molecular level, cell level, and in vivo. Furthermore, we revealed the mechanisms of bone pain associated with bone metastases.