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Cross talk between bone microenvironment and metastatic cancer cell

Cross talk between bone microenvironment and metastatic cancer cell
骨微环境与转移癌细胞之间的串扰
批准号:
17014058
负责人:
YONEDA Toshiyuki
金额:
$27.78万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
Along with increasing of breast and prostate cancer patients, the metastases of cancer into bone has been important issues. It is, therefore, necessary to establish effective solutions for the metastases. Bone resorption and bone formation are active in bone tissues where several types of cells, including immune cells, hematopoietic cells, adipocytes and neural cells, are present. In this study, we examined cross-talk between cancer and bone tissues at molecular level, cell level, and in vivo. Furthermore, we revealed the mechanisms of bone pain associated with bone metastases.
期刊论文(44)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1038/sj.onc.1211025
发表时间: 2008-06-05
期刊: ONCOGENE
影响因子: 8
作者: [Oxmann, D., Held-Feindt, J., Mentlein, R.]
通讯作者: Mentlein, R.
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
在 4T1/luc 小鼠乳腺癌模型中,5-脱氧-5-氟尿苷和卡培他滨优先抑制骨转移。
DOI: --
发表时间: 2005
期刊: Oncol Report 14
影响因子: --
作者: [Hiraga T, Hata K, Ikeda F, Kitagaki J, Fujimoto-Ouchi K, Tanaka Y, Yoneda T.]
通讯作者: Yoneda T.
DOI: 10.1074/jbc.m611569200
发表时间: 2007-03-16
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Block, Karen, Gorin, Yves, Abboud, Hanna E.]
通讯作者: Abboud, Hanna E.
DOI: 10.1007/s10549-007-9504-0
发表时间: 2007-12-01
期刊: BREAST CANCER RESEARCH AND TREATMENT
影响因子: 3.8
作者: [Schmid, Bernd C., Rezniczek, Guenther A., Zeillinger, Robert]
通讯作者: Zeillinger, Robert
41
    Molecular mechanim of cancer-associated bone pain caused by protons
    • 批准号:
      23390422
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.31万
    • 财政年份:
      2011
    • 负责人:
      YONEDA Toshiyuki
    • 依托单位:
    Identification of genes involved in biological crosstalk between cancer and bone
    • 批准号:
      23659870
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2011
    • 负责人:
      YONEDA Toshiyuki
    • 依托单位:
    Integrative Study of transcriptional network systems during enchondral ossification
    • 批准号:
      20229010
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $136.53万
    • 财政年份:
      2008
    • 负责人:
      YONEDA Toshiyuki
    • 依托单位:
    Investigation of molecular mechanisms of Sox9 transcriptional factory during enchandral ossification
    • 批准号:
      17209059
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $29.95万
    • 财政年份:
      2005
    • 负责人:
      YONEDA Toshiyuki
    • 依托单位:
    国内基金
    海外基金
    高糖/PH双响应智能水凝胶体系GZ/V/B@HPP修复糖尿病骨缺损
    高活性肽-金属离子-骨水泥三重整合3D打印复合支架在糖尿病足创面修复中的作用机制研究
    • 批准号:
      JCZRLH202600954
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
    • 依托单位:
    构建靶向类风湿性关节炎炎症-骨代谢失衡的PSO/Alg-Sr水凝胶及其治疗机制研究
    基于温阳化湿理论健骨方治疗膝骨关节炎的临床疗效及机制研究