Cross talk between bone microenvironment and metastatic cancer cell

骨微环境与转移癌细胞之间的串扰

• 批准号: 17014058
• 负责人: YONEDA Toshiyuki
• 金额: $ 27.78万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17014058/
• 关键词: 癌; 骨; 破骨細胞; 骨芽細胞; クロストーク; サイトカイン; 増殖因子; 疼痛; 骨転移; レプチン

Along with increasing of breast and prostate cancer patients, the metastases of cancer into bone has been important issues. It is, therefore, necessary to establish effective solutions for the metastases. Bone resorption and bone formation are active in bone tissues where several types of cells, including immune cells, hematopoietic cells, adipocytes and neural cells, are present. In this study, we examined cross-talk between cancer and bone tissues at molecular level, cell level, and in vivo. Furthermore, we revealed the mechanisms of bone pain associated with bone metastases.

随着乳腺癌和前列腺癌患者的增加，癌症骨转移已成为重要问题。因此，有必要针对转移建立有效的解决方案。骨吸收和骨形成在骨组织中活跃，骨组织中存在多种类型的细胞，包括免疫细胞、造血细胞、脂肪细胞和神经细胞。在这项研究中，我们在分子水平、细胞水平和体内检查了癌症和骨组织之间的串扰。此外，我们揭示了与骨转移相关的骨痛机制。

项目成果

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

• DOI: 10.1038/sj.onc.1211025
• 发表时间: 2008-06-05
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Oxmann, D.;Held-Feindt, J.;Mentlein, R.
• 通讯作者: Mentlein, R.

Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.

在 4T1/luc 小鼠乳腺癌模型中，5-脱氧-5-氟尿苷和卡培他滨优先抑制骨转移。

• 发表时间: 2005
• 期刊: Oncol Report 14
• 作者: Hiraga T;Hata K;Ikeda F;Kitagaki J;Fujimoto-Ouchi K;Tanaka Y;Yoneda T.
• 通讯作者: Yoneda T.

NAD(P)H Oxidases regulate HIF-2α protein expression

• DOI: 10.1074/jbc.m611569200
• 发表时间: 2007-03-16
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Block, Karen;Gorin, Yves;Abboud, Hanna E.
• 通讯作者: Abboud, Hanna E.

The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells

• DOI: 10.1007/s10549-007-9504-0
• 发表时间: 2007-12-01
• 期刊: BREAST CANCER RESEARCH AND TREATMENT
• 影响因子: 3.8
• 作者: Schmid, Bernd C.;Rezniczek, Guenther A.;Zeillinger, Robert
• 通讯作者: Zeillinger, Robert

Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.

• DOI: 10.1002/ijc.23625
• 发表时间: 2008-09-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Bu, Guojun;Lu, Wenyan;Liu, Chia-Chen;Selander, Katri;Yoneda, Toshiyuki;Hall, Christopher;Keller, Evan T.;Li, Yonghe
• 通讯作者: Li, Yonghe