Identification of genes involved in biological crosstalk between cancer and bone
Identification of genes involved in biological crosstalk between cancer and bone
批准号:
23659870
负责人:
YONEDA Toshiyuki
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Crosstalk between cancer cells and bone microenvironments is critical to the development and progression of bone metastases. To determine the molecular basis of bone metastasis, we attempted to uncover the molecules that are expressed in breast cancer cells under the influences of bone microenvironments. We have identified 154 genes by microarray analysis. We found that docking protein NEDD9 that is up-regulated by bone-derived TGF・・is critical to the development of bone metastasis. Further determination of the function of genes identified by this study may lead to design new molecular therapeutic approaches for the treatment of bone metastasis.
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DOI:
10.1158/0008-5472.can-11-3061
发表时间:
2012-08-15
期刊:
Cancer research
影响因子:
11.2
作者:
[Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR, Yoneda T]
通讯作者:
Yoneda T
NEDD9は乳がん細胞の上皮間葉転換を促進する
NEDD9促进乳腺癌细胞上皮间质转化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[波多賢二, 森田祥弘,中西雅子,西庄俊彦,虫明 仁, 由良義明,米田俊之]
通讯作者:
由良義明,米田俊之
骨微小環境と癌
骨微环境与癌症
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Soichi Tanaka, Kenji Hata, Toshiyuki Yoneda, 米田俊之]
通讯作者:
米田俊之
骨はがん細胞のチューター
骨骼是癌细胞的导师
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kenji Hata, Yoshihiro Morita, Jin Mushiake, Masako Nakanishi, Toshihiko Nishisho, Toshiyuki Yoneda, 米田俊之]
通讯作者:
米田俊之
がん骨転移のバイオロジーとマネージメント
癌症骨转移的生物学和治疗
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[布施谷仁志, 川股知之, 川股知之, 川股知之, 川股知之, 川股知之, 川股知之, 川股知之, 川股知之, 川股知之]
通讯作者:
川股知之
共 17 条
Molecular mechanim of cancer-associated bone pain caused by protons
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批准号:23390422
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.31万
-
财政年份:2011
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负责人:YONEDA Toshiyuki
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依托单位:
Integrative Study of transcriptional network systems during enchondral ossification
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批准号:20229010
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$136.53万
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财政年份:2008
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负责人:YONEDA Toshiyuki
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依托单位:
Investigation of molecular mechanisms of Sox9 transcriptional factory during enchandral ossification
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批准号:17209059
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.95万
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财政年份:2005
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负责人:YONEDA Toshiyuki
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依托单位:
Cross talk between bone microenvironment and metastatic cancer cell
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批准号:17014058
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$27.78万
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财政年份:2005
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负责人:YONEDA Toshiyuki
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依托单位:
Cloning of the molecules associated with bone metastases of cancers and its characterization
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批准号:11557136
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.64万
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财政年份:1999
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负责人:YONEDA Toshiyuki
-
依托单位:
The Regulation of Bone-Remodeling by Signals mediated by Phosphorylation
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批准号:11307041
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$24.16万
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财政年份:1999
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负责人:YONEDA Toshiyuki
-
依托单位:
海外基金