Establishment of Bio-nanotool for Local-environmental Measurement and Control by Nano-assembly System

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Recently, analysis and control of biological system, especially for biological cell which is one of the primitive units of biological system, have been widely investigated. The important technique is to control and observe their local environment dynamically. However, the high precision measurement of electrochemical gradient, ionic concentration, and so on, is basically difficult in nano-scale until now. And, low/noninvasive measurement techniques for their physical/chemical properties are also needed.In this research, we established bio-nanotools to measure and control the local environment of biological cells based on nanomanipulation technique by integrating material science, measurement/control/fabrication technologies. We proposed novel local environmental measurement and control technique by applying nano-meter scale bio-nanotools to micro-meter scale biological cell.