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Studies on assembly, maintenance, and reorganization of replication fork complexes

Studies on assembly, maintenance, and reorganization of replication fork complexes
复制叉复合物的组装、维护和重组研究
批准号:
17080006
负责人:
TSURIMOTO Toshiki
金额:
$87.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
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英文摘要
The core structure of chromosomes is organized during DNA replication. We have studied assembly and dynamics of the replication fork complex of human and archaeal cells. We identified novel proteins from human cells, interacting with replication clamp PCNA, loader complex RFC and their paralogs. These results will provide new insights on coupling between DNA replication and maintenance of genome integrity. We also studied structures and functions of archaeal replication proteins, and demonstrated molecular assemblies of the replication fork during progression and upon DNA damage response.
期刊论文(174)
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会议论文
超好熱性アーキアPyorcoccus furiosus由来複製開始因子Cdc6/Orc1の生化学的解析
超嗜热古菌激烈热球菌复制起始因子 Cdc6/Orc1 的生化分析
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Sawa, M., Masai, H., 吉用武弘, 藪内 隼人, 秋由真季]
通讯作者: 秋由真季
Mechanism of replication machinery assembly as revealed by the DNA ligase-PCNA-DNA complex architechture
DNA 连接酶-PCNA-DNA 复合体架构揭示的复制机器组装机制
DOI: --
发表时间: 2009
期刊: Proc. Natl. Acad. Sci. USA. 106
影响因子: --
作者: [Mayanagi K, Kiyonari S, Saito M, Shirai T, Ishino Y, Morikawa K.]
通讯作者: Morikawa K.
DOI: --
发表时间: 2009
期刊: 蛋白質核酸酵素 54
影响因子: --
作者: [Kobayashi, T., 石野園子]
通讯作者: 石野園子
DNA damage induced ubiquitylation of RFC2 subunit of RFC complex
DNA 损伤诱导 RFC 复合物 RFC2 亚基泛素化
DOI: --
发表时间: 2008
期刊: J Biol Chem. 283
影响因子: --
作者: [Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T.]
通讯作者: Todo T.
141
    Researches on functional link between DNA replication and chromosomal cohesion through PCNA clamp
    • 批准号:
      17370064
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.02万
    • 财政年份:
      2005
    • 负责人:
      TSURIMOTO Toshiki
    • 依托单位:
    Studies on interfaces between DNA replication and DNA damage responses through multiple clamp and clamp loader proteins
    AN IMPROVED IN VIVO DNA FOOT PRINTING BY A NON-RADIOISOTOPE DNA
    • 批准号:
      07558229
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $0.9万
    • 财政年份:
      1995
    • 负责人:
      TSURIMOTO Toshiki
    • 依托单位:
    ISOLATION OF DNA HELICASES REQUIRED FOR HUMAN CHROMOSOMAL DNA REPLICATION
    海外基金