Molecular mechanism of regulation of cancer cell apoptosis by plasma membrane-associated sialidase

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Aberrant sialylation is a characteristic feature associated with malignant properties, including invasiveness and metastatic potential. To elucidate the mechanism and provide valuable new information for diagnosis and therapy, our studies have focused on sialidase, a key enzyme for degradation of sialic acid-containing compounds. Our present study has revealed that plasma membrane-associated sialidase is markedly up-regulated in various human cancers and leads to suppression of apoptosis of cancer cells through activation of cell growth signaling pathway.