Cardiovascular damage protection by APP/APLP2 (A06)

APP/APLP2 保护心血管损伤 (A06)

• 批准号: 505069674
• 金额: --
• 依托单位: Abteilung II: Pharmakologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/505069674?language=en
• 关键词: Cardiovascular; damage; protection; APP; APLP2

Amyloid precursor protein (APP) and its close homologue APLP2 are expressed in cells of the cardio¬vascular system, but their function is unknown. Starting from our observation that mice with endothelial cell-specific loss of APP and APLP2 show exaggerated responses to myocardial ischemia, we hypothesize that APP/APLP2 are involved in protection against acute damage. We will analyze the protective function of APP/APLP2 in endothelial cells and other cells of the cardiovascular system using different ischemia models, conditional knock-outs and mutant alleles. In vivo analyses will be accompanied by in vitro studies to elucidate the mechanisms underlying the protective function of APP/APLP2.

淀粉样蛋白前体蛋白（APP）及其同源物APLP2在心血管系统细胞中表达，但其功能尚不清楚。从我们观察到内皮细胞特异性APP和APLP2缺失的小鼠对心肌缺血的反应放大开始，我们假设APP/APLP2参与了对急性损伤的保护。我们将通过不同的缺血模型、条件敲除和突变等位基因来分析APP/APLP2对内皮细胞和心血管系统其他细胞的保护功能。在体内分析的同时，还将进行体外研究，以阐明APP/APLP2保护功能的机制。