Functional analysis of the cancer development from fatty acid metabolism and oxidative phosphorylation of HCC based on NAFLD/NASH

基于NAFLD/NASH的HCC脂肪酸代谢和氧化磷酸化癌变的功能分析

• 批准号: 16K19939
• 负责人: NAKAGAWA Shigeki
• 金额: $ 2.5万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K19939/
• 关键词: 肝細胞癌; 非アルコール性脂肪肝; 遺伝子発現; TM6SF2; NAFLD; NASH; 癌代謝; 脂肪肝; NAFLD/NASH肝細胞癌; 脂肪酸代謝; 酸化ストレス; 薬剤感受性予測因子

项目成果

Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma

• DOI: 10.1016/j.hpb.2018.03.018
• 发表时间: 2018-10-01
• 期刊: HPB
• 影响因子: 2.9
• 作者: Nakagawa, Shigeki;Okabe, Hirohisa;Baba, Hideo
• 通讯作者: Baba, Hideo

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma.

• DOI: 10.1136/gutjnl-2016-312268
• 发表时间: 2017-07
• 期刊: Gut
• 影响因子: 24.5
• 作者: Bollard J;Miguela V;Ruiz de Galarreta M;Venkatesh A;Bian CB;Roberto MP;Tovar V;Sia D;Molina-Sánchez P;Nguyen CB;Nakagawa S;Llovet JM;Hoshida Y;Lujambio A
• 通讯作者: Lujambio A

Lymphocitye 25-gene signature can predict the prognosis of the patients who underwent surgery for pancreatic cancer

淋巴细胞25基因特征可以预测接受胰腺癌手术的患者的预后

• 发表时间: 2018
• 作者: Shigeki Nakagawa、Yo-ichi Yamashita;Hirohisa Okabe;Katsunori Imai;Hidetoshi Nitta;Akira Chikamoto;Hideo Baba
• 通讯作者: Hideo Baba

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

• DOI: 10.1016/j.ccell.2016.11.004
• 发表时间: 2016-12-12
• 期刊: Cancer cell
• 影响因子: 50.3
• 作者: Nakagawa S;Wei L;Song WM;Higashi T;Ghoshal S;Kim RS;Bian CB;Yamada S;Sun X;Venkatesh A;Goossens N;Bain G;Lauwers GY;Koh AP;El-Abtah M;Ahmad NB;Hoshida H;Erstad DJ;Gunasekaran G;Lee Y;Yu ML;Chuang WL;Dai CY;Kobayashi M;Kumada H;Beppu T;Baba H;Mahajan M;Nair VD;Lanuti M;Villanueva A;Sangiovanni A;Iavarone M;Colombo M;Llovet JM;Subramanian A;Tager AM;Friedman SL;Baumert TF;Schwarz ME;Chung RT;Tanabe KK;Zhang B;Fuchs BC;Hoshida Y;Precision Liver Cancer Prevention Consortium
• 通讯作者: Precision Liver Cancer Prevention Consortium

A stromal liver gene signature predictive of HCC risk across all liver disease etiologies

肝基质基因特征可预测所有肝病病因中的 HCC 风险

• 发表时间: 2018
• 作者: Shigeki Nakagawa;Naoki Umesaki;Takanobu Yamao Yuki Kitano;Kensuke Yamamura;Kota Arima;Tatsunori Miyata;Takayoshi Kaida;Yujin Hoshida;Katsunori Imai,Daisuke Hashimoto;Yoichi Yamashita;Akira Chikamoto;Hideo Baba
• 通讯作者: Hideo Baba