NMR console (replacement) for 500 MHz spectrometer

位于波恩大学药物研究所“化学分析”平台的核磁共振实验室负责处理大量的核磁共振波谱问题。现有的500 MHz核磁共振谱仪是药剂部核磁共振分析的主要设备。该仪器对利用合成有机化学的研究小组的所有研究项目都是必不可少的，并用于小分子、肽仿制、蛋白质降解靶向分子(PROTAC)、大环和天然产物等的结构阐明和表征。现有控制台的备件不再可用，更换控制台是不可避免的。此外，为了提供现代化的用户友好操作，必须更换控制单元。目前，500兆赫的核磁共振波谱仪仍需“手工”垫片。因此，更换核磁共振控制台、更换探头和软件升级有望显著节省和提高核磁共振分析的效率。由于核磁共振样品的数量很多，现有的500 MHz仪器的使用率非常高，如果出现故障，将对药剂部的研究结果产生重大影响。因此，要求对现有的500 MHz核磁共振波谱仪进行现代化改造。

The NMR laboratory in the platform "Chemical Analysis" at the Pharmaceutical Institute of the University of Bonn is responsible for the processing of numerous NMR spectroscopic questions. The existing 500 MHz NMR spectrometer is a mainstay of NMR analysis in the Department of Pharmacy. The instrument is essential for all research projects of the research groups utilizing synthetic organic chemistry and is used for structure elucidation and characterization of small molecules, peptidomimetics, proteolysis-targeting molecules (PROTACs), macrocycles and natural products, among others. Spare parts for the existing console are no longer available and the replacement of the console is inevitable. Furthermore, the replacement of the control unit is necessary to provide a modern user-friendly operation. Currently, the 500 MHz NMR spectrometer still has to be shimmed "by hand". Therefore, the NMR console replacement, the replacement of probehead and a software upgrade are expected to significantly economize and increase the efficiency of NMR analysis. The existing 500 MHz instrument is very heavily utilized due to the high number of NMR samples and a failure would have a dramatic impact on the research results of the Department of Pharmacy. Therefore, the modernization of the existing 500 MHz NMR spectrometer is requested.