REQUEST TO PURCHASE A 600 MHZ NMR REPLACEMENT CONSOLE AND COLD PROBE

请求购买 600 MHZ NMR 替换控制台和冷探头

基本信息

  • 批准号:
    8447885
  • 负责人:
  • 金额:
    $ 43.67万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The Washington University High Resolution NMR Facility is requesting funds to purchase a state- of-the-art replacement console and a high-end technology cold probe for its core 600-MHz NMR instrument. The combination of new console and cold probe will markedly improve signal-to-noise and instrument stability, thus greatly facilitating ongoing biochemistry and biomedical research programs, ultimately impacting human health. This request will modernize the highest field spectrometer of the University-wide NMR Facility that serves 40 separate research groups, spanning departments of Anesthesiology, Biochemistry & Molecular Biophysics, Biology, Biomedical Engineering, Cardiology, Chemistry, Infectious Diseases, Internal Medicine, Neurology, Ophthalmology, Pathology, Pharmacology & Developmental Biology, Physics, and Radiology (Division of Radiation Sciences). The NMR Facility supports and maintains six instruments and is staffed with seasoned PhD-level professionals who are committed to user training and collaborative research. The Facility is in its 28th year of operation, is open and available 24 hours a day, 365 days a year, and is committed to serving its extensive user base. This funding request is prompted by the need to maintain the Facility's capabilities in the face of extraordinary technological advances over the past decade, to reduce instrument down-time and maintenance expense, and importantly, to add an ultra-high-sensitivity cold probe that will enable new experiments and provide experimental efficiencies via significantly enhanced signal sensitivity. The scientific research described in ths proposal spans user groups with longstanding interests in fundamental biological, biochemical, and biomedical research and clinically related health questions. These including research areas directed toward light initiated alterations of DNA structure, the creation of molecular patterns that mimic neural communication networks, understanding markers for the genesis and recognition of cancer, understanding structure and genesis of amyloid precursors, elucidation of tissue damage pathways caused by reactive oxidative molecules, and deciphering the altered metabolism of the diabetic heart as well as metabolism alterations associated with carbohydrate-poor diet. This request is made with a financial matching fund commitment from Washington University in the sum of $195,000.
描述(由申请人提供):华盛顿大学高分辨率核磁共振设施正在申请资金,为其核心600 MHz核磁共振仪器购买最先进的更换控制台和高端技术冷探头。新控制台和冷探头的结合将显著提高信噪比和仪器稳定性,从而大大促进正在进行的生物化学和生物医学研究计划,最终影响人类健康。这一要求将现代化的大学范围内的NMR设施,服务于40个独立的研究小组,跨越麻醉学,生物化学和分子生物物理学,生物学,生物医学工程,心脏病学,化学,传染病,内科学,神经病学,眼科学,病理学,药理学和发育生物学,物理学和放射学(辐射科学部)部门的最高场光谱仪。NMR设施支持和维护六台仪器,并配备了经验丰富的博士级专业人员,他们致力于用户培训和合作研究。该设施是在其 运营28年,全年365天,每天24小时开放,并致力于为其广泛的用户群提供服务。提出这一供资请求的原因是,需要在过去十年技术取得巨大进步的情况下保持该设施的能力,减少仪器停机时间和维护费用,而且重要的是,需要增加一个超高灵敏度冷探头,以便能够进行新的实验,并通过显著提高信号灵敏度来提高实验效率。该提案中描述的科学研究涵盖了对基础生物学、生物化学和生物医学研究以及临床相关健康问题长期感兴趣的用户群体。这些研究领域包括光引发的DNA结构改变,模拟神经通讯网络的分子模式的创建,理解癌症发生和识别的标志物,理解淀粉样蛋白前体的结构和发生,阐明由反应性氧化分子引起的组织损伤途径,以及破译糖尿病心脏的代谢改变以及与碳水化合物缺乏饮食相关的代谢改变。这项要求得到了华盛顿大学195 000美元的财政配套资金承诺。

项目成果

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JOSEPH J. H. ACKERMAN其他文献

JOSEPH J. H. ACKERMAN的其他文献

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{{ truncateString('JOSEPH J. H. ACKERMAN', 18)}}的其他基金

21st Century Imaging Sciences: Graduate Student Training
21 世纪成像科学:研究生培训
  • 批准号:
    9280509
  • 财政年份:
    2012
  • 资助金额:
    $ 43.67万
  • 项目类别:
21st Century Imaging Sciences: Graduate Student Training
21 世纪成像科学:研究生培训
  • 批准号:
    9768457
  • 财政年份:
    2012
  • 资助金额:
    $ 43.67万
  • 项目类别:
21ST CENTURY IMAGING SCIENCES: GRADUATE STUDENT TRAINING
21 世纪成像科学:研究生培训
  • 批准号:
    10411772
  • 财政年份:
    2012
  • 资助金额:
    $ 43.67万
  • 项目类别:
21st Century Imaging Sciences: Graduate Student Training
21 世纪成像科学:研究生培训
  • 批准号:
    10264790
  • 财政年份:
    2012
  • 资助金额:
    $ 43.67万
  • 项目类别:
21st Century Imaging Sciences: Graduate Student Training
21 世纪成像科学:研究生培训
  • 批准号:
    10006823
  • 财政年份:
    2012
  • 资助金额:
    $ 43.67万
  • 项目类别:
REQUEST TO PURCHASE A VARIAN HIGH RESOLUTION NMR REPLACEMENT CONSOLE
请求购买 VARIAN 高分辨率 NMR 替换控制台
  • 批准号:
    7794735
  • 财政年份:
    2010
  • 资助金额:
    $ 43.67万
  • 项目类别:
MRI CONSOLE UPGRADE FOR SMALL-ANIMAL 12-T SCANNER
小动物 12-T 扫描仪的 MRI 控制台升级
  • 批准号:
    7794513
  • 财政年份:
    2010
  • 资助金额:
    $ 43.67万
  • 项目类别:
REQUEST TO PURCHASE A 400 MHZ NMR SPECTROMETER
请求购买 400 MHZ 核磁共振波谱仪
  • 批准号:
    7794739
  • 财政年份:
    2010
  • 资助金额:
    $ 43.67万
  • 项目类别:
Small Animal Cancer Imaging Core
小动物癌症成像核心
  • 批准号:
    8181211
  • 财政年份:
    2010
  • 资助金额:
    $ 43.67万
  • 项目类别:
2009 World Molecular Imaging Congress
2009年世界分子影像大会
  • 批准号:
    7750444
  • 财政年份:
    2009
  • 资助金额:
    $ 43.67万
  • 项目类别:

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