REQUEST TO PURCHASE A VARIAN HIGH RESOLUTION NMR REPLACEMENT CONSOLE

请求购买 VARIAN 高分辨率 NMR 替换控制台

• 批准号: 7794735
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 23.94万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-04 至 2011-02-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794735
• 关键词: Aging; Anesthesiology; Area; Back; Biochemistry; Biophysics; Cardiology; Chemistry; Commit; Communication; DNA Structure; Engineering; Funding; Health; Heart; Hour; Housing; Internal Medicine; Light; Magic; Magnetic Resonance; Maintenance; Malignant Neoplasms; Metabolism; Molecular; Molecular Biology; Molecular Structure; Neurology; Ophthalmology; Organism; Pathology; Pharmacology; Physics; Principal Investigator; Radiation Oncology; Radiology Specialty; Research; Resolution; Resources; Sampling; Seasons; Services; Sum; Time; Tissues; Training; Universities; Washington; base; diabetic; instrument; interest; relating to nervous system

DESCRIPTION (provided by applicant): The Washington University High Resolution NMR Facility requests funding to purchase a Varian DirectDriveT console for an aging 500 MHz NMR instrument and a magic angle sample spinning NanoprobeT to allow for studies of metabolite profiles from cancer tissues. These requests are for supplementing and modernizing a shared magnetic resonance resource that serves 38 separate research groups spanning departments of Anesthesiology, Biochemistry & Molecular Biophysics, Chemistry, Cardiology, Engineering, Internal Medicine, Neurology, Ophthalmology, Pathology, Pharmacology & Molecular Biology, Physics, Radiation Oncology, and Radiology. The NMR Facility is an active resource housing five instruments and staffed with seasoned professionals committed to user training and collaborative research. The Facility is open and available 24 hours a day, 365 days a year and committed to service for its extensive user base. This request is prompted by significant down time and maintenance expense associated with the existing Facility 500 MHz instrument that dates back to 1986. This instrument has served research needs for dozens of principal investigators for over two decades and is now dated and unreliable. The scientific basis for this proposal spans a user group with longstanding interests in health related issues. These including research areas of light initiated alterations of DNA structure, the creation of molecular structures that mimic neural communication networks, understanding markers for the genesis of and recognition of cancer, tissue damage caused by reactive oxidative molecules in living systems, and understanding the altered metabolism of the diabetic heart. This request, $314,395, is made with a financial matching commitment from Washington University in the sum of $75,000.

描述（由申请人提供）：华盛顿大学高分辨率核磁共振设施申请资金，用于购买瓦里安DirectDriveT控制台，用于老化的500 MHz核磁共振仪器和魔角样品旋转NanoprobeT，用于研究癌症组织的代谢物谱。这些要求是为了补充和现代化一个共享的磁共振资源，该资源服务于38个独立的研究小组，包括麻醉学、生物化学和分子生物物理学、化学、心脏病学、工程学、内科、神经病学、眼科学、病理学、药理学和分子生物学、物理学、放射肿瘤学和放射学。核磁共振设施是一个活跃的资源，拥有五种仪器，并配备了经验丰富的专业人员，致力于用户培训和合作研究。该设施每年365天，每天24小时开放，并致力于为其广泛的用户群提供服务。这一要求是由于现有设施500mhz仪器的大量停机时间和维护费用导致的，该仪器可追溯到1986年。该仪器为数十名主要研究人员提供了二十多年的研究需求，现在已经过时且不可靠。这项建议的科学依据涵盖了对健康相关问题长期感兴趣的用户群体。这些研究领域包括光引发的DNA结构改变，模拟神经通信网络的分子结构的创建，了解癌症发生和识别的标记，生命系统中活性氧化分子引起的组织损伤，以及了解糖尿病心脏代谢的改变。这笔314 395美元的请求是与华盛顿大学提供的总额为75 000美元的财政匹配承诺一起提出的。