Replacement purchase for a 500 MHz NMR console

BNMRZ的研究小组利用核磁共振光谱学来获得生理和疾病相关细胞过程基础的基本生物过程的分子和机制见解。该应用程序涉及500 MHz WB固态核磁共振光谱仪的替换控制台。研究课题涉及淀粉样蛋白原纤维、膜蛋白和病毒组装的蛋白质结构和动力学分析。另一个重点领域是MAS固态核磁共振方法的发展。500mhz光谱仪对这项工作至关重要，因为MAS固态核磁共振实验将首先在低磁场下实施和测试，然后在更高磁场强度下进行涉及生物学上感兴趣的样品的实验。

The research groups at the BNMRZ employ NMR spectroscopy to obtain molecular and mechanistic insight for essential biological processes that underlie physiological and diseaselinked cellular processes. The application concerns a replacement console for a 500 MHz WB solid-state NMR spectrometer. Research topics involve the analysis of protein structure and dynamics of amyloid fibrils, membrane proteins and virus assemblies. An additional focus area is the development of methods for MAS solid-state NMR. The 500 MHz spectrometer is essential for this work, as MAS solid-state NMR experiments will be implemented and tested first at low field, before experiments involving biologically interesting samples will be performed at higher magnetic field strengths.