Development of new therapeutic agents for brain tumor using protein therapy

硼中子俘获治疗(BNCT)是一种新型的肿瘤治疗方法，它可以选择性地靶向肿瘤，而不会对正常组织造成过度的辐射损伤。在本项目中，我们开发了两种新型的BNCT治疗药物：利用蛋白质疗法的细胞穿透性多肽或纳米粒子，它们有效地将货物运送到细胞内，将^&lt；10&gt；B作为BNCT药物运送到肿瘤细胞中。在使用培养的肿瘤细胞的体外研究和使用荷瘤小鼠的体内研究中，这些药物只在肿瘤中观察到。结果表明，我们的系统利用多肽或纳米颗粒提供了一种有效的方法，在BNCT中选择性地将^&lt；10&gt；B输送到肿瘤细胞中。

Boron neutron capture therapy (BNCT) is a novel cancer treatment modality that can selectively target the tumor without causing excessive radiation damage to the normal tissues. In this project, we developed 2 types of new therapeutic agents for BNCT : cell-penetrating peptides using the protein therapy or nanoparticles, which are effective of delivering cargo into cells, to deliver ^<10>B into the tumor cells as BNCT agents. In both in-vitro studies using the cultured tumor cells and in-vivo studies using tumor-bearing mice, these agents were only observed in the tumor. The results suggest that our systems utilizing peptides or nanoparticles provide an effective means of delivering ^<10>B into tumor cells selectively in BNCT.