Analysis of cancer suppressor gene PTEN and its regulation
Analysis of cancer suppressor gene PTEN and its regulation
批准号:
20249019
负责人:
SUZUKI Akira
金额:
$31.95万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
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英文摘要
We generated various tissuespecific PTENdeficient mice and found the novel functions of PTEN in vivo.(2) We found PICT1 binds and stabilizes PTEN protein. Moreover, we found PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus.(3) We found PBP1 binds and activates lipid phosphatase activity of PTEN, and strongly represss the Akt activation in vitro. Thus, we found the novel functions of PTEN and the mechanism of its regulation.
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新規遺伝子PICT1(GLTSCR2)によるp53経路や腫瘍進展の制御~核小体を起点とするp53制御機構~
新基因 PICT1 (GLTSCR2) 对 p53 通路和肿瘤进展的调节 ~ 源自核仁的 p53 控制机制 ~
DOI:
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发表时间:
2011
期刊:
影响因子:
--
作者:
[河原康一, 西尾美希, 三森功士, 古後龍之介, 濱田浩一, 佐々木雅人, 前濱朝彦, 森正樹, 鈴木聡]
通讯作者:
鈴木聡
Mats欠損による個体発生と腫瘍発症制御Matsによる個体発生と腫瘍発症の制御
Mats 缺陷对个体发育和肿瘤发育的控制 Mats 缺陷对个体发育和肿瘤发育的控制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鈴木聡, 濱田浩一, 西尾美希, 王嘉, 伊東文祥, 河原康一, 佐々木雅人, 佐々木雄彦]
通讯作者:
佐々木雄彦
「ホスホリパーゼ」、「ホスホリパーゼC」ArPIs3キナーゼ」生物学辞典
“磷脂酶”、“磷脂酶 C”ArPIs3 激酶”生物学词典
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Nishida H, Sohara E, Alessi DR, Nomura N, Rai T, Sasaki S, Uchida S, 土屋秋穂, Abe M, 鈴木聡]
通讯作者:
鈴木聡
癌抑制qMobloblob1の機能解析
抑癌基因qMobloblob1的功能分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[西尾美希, 鈴木聡ら全9名9番目]
通讯作者:
鈴木聡ら全9名9番目
PTEN regulates the proliferation and differentiation of the mammalian cochlea hair cells
PTEN 调节哺乳动物耳蜗毛细胞的增殖和分化
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Youyi Dong, Akira Suzuki, MasaakiTokuda,ら全6名5番目]
通讯作者:
MasaakiTokuda,ら全6名5番目
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