Can Occlusal Evaluation Determinate Future Maxillofacial Morphology of Children with Unilateral Cleft Lip and Palate?

咬合评估能否确定单侧唇腭裂儿童未来的颌面形态？

• 批准号: 21592598
• 负责人: SUZUKI Akira
• 金额: $ 3.08万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592598/
• 关键词: 口唇裂口蓋裂患者; 咬合評価; 顎顔面形態; 成長; Goslon Yardstick; 継年資料; セファロ分析; 石膏模型; 口唇裂口蓋裂; 顎顔面成長; 頭部X線規格写真; 経年的研究; 歯学; 臨床; 顎顔面発育; Goslon yardstic; 5-year-old index

Two studies were carried out ;(Study A) Correlation analyses between the occlusal relationship evaluated by the Goslon Yardstick and the maxillofacial growth measured from longitudinal cephalographs taken on 85 subjects with unilateral cleft lip and palate at the ages of five, ten, and over fifteen.(Study B) Comparison of maxillofacial growth patterns from 3-4 months old to fifteen years or older taken on longitudinal cephalographs of 38 male and 46 female CLP subjects among three cleft types ; unilateral cleft lip and alveolus(CLA), unilateral cleft lip and palate(CLP), and isolated cleft palate(CP). The followings were concluded from these two studies(1) Occlusal evaluation by the Five-year-old index or the Goslon Yardstick is a simple measure to represent maxilla-mandibular relationship, but those measures evaluate the outcome of maxillofacial growth until the time.(2) The occlusal evaluation by the Goslon Yardstick at ten years was similar with the one by the Five-year-old index at … More five years, furthermore orthodontic treatment has a tendency to make the outcome of occlusal evaluation better.(3) The outcome of occlusal evaluation has a significant relation with the amount and direction of mandibular growth rather than maxillary growth affected by labioplasty and/or palatoplasty in the subjects with unilateral cleft lip and palate.(4) Occlusal outcome evaluated by the Goslon Yardstick at the age of ten had no significant relation with future maxillofacial growth after then until adulthood. This suggests the maxillofacial growth in puberty may be great and determined the matured facial profile in adult. In this study, there were some CLP subjects who had been classified in good groups by the five-year-old index and the Goslon Yardstick, but underwent Orthognathic surgery in adulthood.(5) From the Study B comparing the longitudinal maxillofacial growth among the subjects with CLA, CLP, and CP, both labial and palatal plastic surgeries affected maxillofacial growth, but not mandibular growth. As our surgical procedure for palatal repair was the same one, the modified V-Y push back method, the effects of surgical procedures on maxillofacial growth will be evaluated and compared by the inter-centers study in future.(6) This study suggests that final maxillofacial morphology in adulthood will be determined by the genetic growth potential of the growing CLP children, especially in puberty. We need to evaluate the effects of more factors ; ones by plastic surgeries, genetic background, in order to predict the matured maxillofacial growth of the subjects with cleft lip and/or palate. Less

进行了两项研究;（研究A）之间的相关性分析评价的咬合关系的Goslon标尺和颌面部生长测量的纵向头片85例单侧唇腭裂患者在5岁，10岁，15岁以上。（研究B）比较了38名男性和46名女性CLP受试者从3-4个月大到15岁或更大时的颌面生长模式，这些受试者属于三种类型的腭裂：单侧唇裂和齿槽裂（CLA）、单侧唇腭裂（CLP）和孤立性腭裂（CP）。研究结果表明：（1）5岁指数和Goslon标准是一种简单的评价颌骨关系的方法，但这些方法评价的是当时的颌骨生长状况。(2)10岁时Goslon标准咬合评估与5岁时的指数咬合评估相似， ...更多信息 5年来，正畸治疗有使咬合评估结果更好的趋势。(3)在单侧唇腭裂患者中，咬合评估的结果与下颌骨生长的量和方向有显著的关系，而不是与唇和/或腭成形术影响的上颌骨生长有关。(4)在10岁时，由Goslon Yardstick评估的咬合结果与之后直到成年的未来颌面部生长没有显着关系。提示青春期颌面部发育可能较大，并决定了成年后颌面部轮廓的发育。在这项研究中，有一些CLP受试者被5岁指数和Goslon Yardstick分类为良好组，但在成年后接受了颌外科手术。(5)研究B比较了CLA、CLP和CP受试者的纵向颌面生长，唇和腭整形手术均影响颌面生长，但不影响下颌骨生长。由于我们的腭部修复手术方法相同，即改良V-Y后推法，因此手术方法对颌面部生长的影响将在未来的跨中心研究中进行评估和比较。(6)这项研究表明，最终的颌面部形态在成年期将决定的遗传生长潜力的增长CLP儿童，特别是在青春期。我们需要评估更多的因素的影响，整形手术，遗传背景，以预测唇腭裂患者的成熟颌面部的生长。少

项目成果

口唇裂口蓋裂患者における顎顔面発育の乳幼児期から成人までの経年的変化

唇腭裂患者从婴儿期到成年期颌面发育的长期变化

• 发表时间: 2011
• 作者: Suzuki A;Yoshizaki K;Honda Y;Sasaguri M;Kubota Y;Nakamura N;Ohishi M;Oka M;Tashiro H;Katsuki T;Fujino H.;田村直子,笹栗正明,鈴木陽,光安岳志,辻口友美,新井伸作,松村香織,森悦秀,中村誠司
• 通讯作者: 田村直子,笹栗正明,鈴木陽,光安岳志,辻口友美,新井伸作,松村香織,森悦秀,中村誠司

Retrospective Evaluation of Treatment Outcome in Japanese Children with Complete Unilateral Cleft Lip and Palate

日本完全性单侧唇腭裂儿童治疗效果的回顾性评价

• 发表时间: 2007
• 期刊: Part 1 : 5 Year Olds' Index for Dental Arch Relationships. Cleft Palate-Craniofac J
• 作者: Suzuki A;Yoshizaki K;Honda Y;Sasaguri M;Kubota Y;Nakamura N;Ohishi M;Oka M;Tashiro H;Katsuki T;Fujino H.
• 通讯作者: Fujino H.