Oxidative stress-induced apoptotic cell death pathway after spinal cord injury

脊髓损伤后氧化应激诱导的细胞凋亡途径

• 批准号: 20591704
• 负责人: SUZUKI Akira
• 金额: $ 3万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591704/
• 关键词: 脊髄損傷; 運動ニューロン; アポトーシス; DNA損傷; スーパーオキシド

Ventral horn motor neurons (VMN) are selectively vulnerable to mild spinal cord injury (SCI) ; however, the mechanisms of cell death had not been understood. Mild compression SCI was induced in Sprague-Dawley rats, and superoxide production and apoptotic DNA injury were characterized. Increased superoxide production was observed exclusively in VMN after SCI. Subsequently, a majority of VMN (80%) selectively underwent delayed apoptotic cell death. These results suggest that the oxidative stress plays a pivotal role in apoptotic VMN death after SCI.

脊髓腹角运动神经元(VMN)对轻度脊髓损伤(SCI)具有选择性易感性，但其细胞死亡机制尚不清楚。建立SD大鼠轻度压迫性脊髓损伤模型，以超氧化物歧化产物和DNA损伤为特征。脊髓损伤后，仅在VMN观察到超氧化物歧化产物的增加。随后，大多数VMN(80%)选择性地经历了延迟性凋亡细胞死亡。这些结果表明，氧化应激在脊髓损伤后VMN的凋亡中起着关键作用。

项目成果

Model Mice for Mild-Form Glycine Encephalopathy: Behavioral and Biochemical Characterizations and Efficacy of Antagonists for the Glycine Binding Site of N-Methyl D-Aspartate Receptor

• DOI: 10.1203/pdr.0b013e3181799562
• 发表时间: 2008-09
• 期刊: Pediatric Research
• 影响因子: 3.6
• 作者: Kanako Kojima‐Ishii;S. Kure;A. Ichinohe;T. Shinka;A. Narisawa;Shoko Komatsuzaki;J. Kanno;Fumiaki Kamada;Y. Aoki;H. Yokoyama;M. Oda;T. Sugawara;K. Mizoi;D. Nakahara;Y. Matsubara

Negative Pressure Pulmonary Edema Following Foramen Magnum Decompression for Chiari Malformation Type 1 -case report-

1 型 Chiari 畸形枕骨大孔减压术后出现负压性肺水肿 - 病例报告 -

• 发表时间: 2008
• 期刊: Neurol Med chir 48(3)
• 作者: Hirano Y;Sugawara T;Sato Y;Sato K;Omae T;Sasajima T;Mizoi K
• 通讯作者: Mizoi K

非機能性下垂体腺腫に対するfanctionated stereotactic radiotherapy (FSRT)の長期治療成績

功能性立体定向放射治疗（FSRT）治疗无功能垂体腺瘤的长期治疗结果

• 发表时间: 2010
• 作者: Nishizawa;S;菅原卓;Nishizawa S;菅原卓,東山巨樹,柴田憲一,高橋和孝,笹嶋寿郎;Nishizawa S;鈴木明,羽入紀朋,笹嶋寿郎,高橋和孝,島田直也,柴田憲一,溝井和夫,古賀眞,橋本学
• 通讯作者: 鈴木明,羽入紀朋,笹嶋寿郎,高橋和孝,島田直也,柴田憲一,溝井和夫,古賀眞,橋本学

Long term outcome and adjacent disc degeneration after anterior cervical disctomy and fusion with titanium cylindrical cages.

颈前路椎间盘切除术和钛合金圆柱形融合器融合后的长期结果和邻近椎间盘退变。

• 发表时间: 2009
• 期刊: Acta Neurochir 151
• 作者: Sugawara T;Itoh Y;Hirano Y;Higashiyama N;Mizoi K
• 通讯作者: Mizoi K

頚椎前方アプローチの適応と基本手技

颈椎前路入路的适应证和基本技术

• 发表时间: 2010
• 作者: Nishizawa;S;菅原卓
• 通讯作者: 菅原卓