Oxidative stress-induced apoptotic cell death pathway after spinal cord injury
Oxidative stress-induced apoptotic cell death pathway after spinal cord injury
批准号:
20591704
负责人:
SUZUKI Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Ventral horn motor neurons (VMN) are selectively vulnerable to mild spinal cord injury (SCI) ; however, the mechanisms of cell death had not been understood. Mild compression SCI was induced in Sprague-Dawley rats, and superoxide production and apoptotic DNA injury were characterized. Increased superoxide production was observed exclusively in VMN after SCI. Subsequently, a majority of VMN (80%) selectively underwent delayed apoptotic cell death. These results suggest that the oxidative stress plays a pivotal role in apoptotic VMN death after SCI.
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DOI:
10.1203/pdr.0b013e3181799562
发表时间:
2008-09
期刊:
Pediatric Research
影响因子:
3.6
作者:
[Kanako Kojima‐Ishii;S. Kure;A. Ichinohe;T. Shinka;A. Narisawa;Shoko Komatsuzaki;J. Kanno;Fumiaki Kamada;Y. Aoki;H. Yokoyama;M. Oda;T. Sugawara;K. Mizoi;D. Nakahara;Y. Matsubara]
通讯作者:
Kanako Kojima‐Ishii;S. Kure;A. Ichinohe;T. Shinka;A. Narisawa;Shoko Komatsuzaki;J. Kanno;Fumiaki Kamada;Y. Aoki;H. Yokoyama;M. Oda;T. Sugawara;K. Mizoi;D. Nakahara;Y. Matsubara
Negative Pressure Pulmonary Edema Following Foramen Magnum Decompression for Chiari Malformation Type 1 -case report-
1 型 Chiari 畸形枕骨大孔减压术后出现负压性肺水肿 - 病例报告 -
DOI:
--
发表时间:
2008
期刊:
Neurol Med chir 48(3)
影响因子:
--
作者:
[Hirano Y, Sugawara T, Sato Y, Sato K, Omae T, Sasajima T, Mizoi K]
通讯作者:
Mizoi K
非機能性下垂体腺腫に対するfanctionated stereotactic radiotherapy (FSRT)の長期治療成績
功能性立体定向放射治疗(FSRT)治疗无功能垂体腺瘤的长期治疗结果
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nishizawa, S, 菅原卓, Nishizawa S, 菅原卓,東山巨樹,柴田憲一,高橋和孝,笹嶋寿郎, Nishizawa S, 鈴木明,羽入紀朋,笹嶋寿郎,高橋和孝,島田直也,柴田憲一,溝井和夫,古賀眞,橋本学]
通讯作者:
鈴木明,羽入紀朋,笹嶋寿郎,高橋和孝,島田直也,柴田憲一,溝井和夫,古賀眞,橋本学
頚椎前方アプローチの適応と基本手技
颈椎前路入路的适应证和基本技术
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nishizawa, S, 菅原卓]
通讯作者:
菅原卓
Long term outcome and adjacent disc degeneration after anterior cervical disctomy and fusion with titanium cylindrical cages.
颈前路椎间盘切除术和钛合金圆柱形融合器融合后的长期结果和邻近椎间盘退变。
DOI:
--
发表时间:
2009
期刊:
Acta Neurochir 151
影响因子:
--
作者:
[Sugawara T, Itoh Y, Hirano Y, Higashiyama N, Mizoi K]
通讯作者:
Mizoi K
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