Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements

创新型人工氧载体在治疗循环障碍疾病中的应用

• 批准号: 20249072
• 负责人: KAWAGUCHI Akira
• 金额: $ 30.87万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20249072/
• 关键词: 救急蘇生学; 人工赤血球; 微小循環; 脳梗塞; 創傷治癒; 虚血・再還流; 酸化ストレス; 酸素ラジカル; ナノバイオ; 救命; 救急; エネルギー代謝; 酸素; 外呼吸; 内呼吸; ヘモグロビン; 薬理学; 老化

We evaluated newly developed artificial oxygen carriers(AOCs), such as liposome-encapsulated hemoglobin(LEH), hemocyclodextrin, corphysene-myoglobin, in the animal models of various pathologic conditions derived from circulatory disorder. These AOCs, specifically LEH, have been proved to be protective of the organ function and morphologic structure in ischemia and/or reperfusion injury of the brain, cochlea and skeletal muscle. LEH is shown to be effective in accelerating wound healing in the stomach and skin. LEH is also shown to be inert and safe on intravenous infusion in mice reconstituted with human immune system. The mice remains immunologically intact and normally responding against third party antigens after transfused with a large amount of LEH(20 mL/kg), which may competitively inhibit the antigen processing activity of the host.

我们评估了新开发的人工氧载体（AOCs），如脂质体包裹的血红蛋白（莱赫），血环糊精，肌红蛋白，在各种病理条件下的动物模型，来自循环障碍。这些AOCs，特别是莱赫，已被证明在脑、耳蜗和骨骼肌的缺血和/或再灌注损伤中对器官功能和形态结构具有保护作用。莱赫被证明在加速胃和皮肤的伤口愈合方面是有效的。莱赫也被证明在用人免疫系统重建的小鼠中静脉输注时是惰性和安全的。小鼠在输注大量莱赫（20 mL/kg）后仍保持免疫完整，对第三方抗原的反应正常，这可能会竞争性抑制宿主的抗原加工活性。

项目成果

Possible role of artificial oxygen carriers in transfusion medicine: a retrospective analysis on the current transfusion practice.

• DOI: 10.1111/j.1525-1594.2008.00696.x
• 发表时间: 2009-02
• 期刊: Artificial organs
• 影响因子: 2.4
• 作者: F. Yoshiba;A. Kawaguchi;O. Hyodo;T. Kinoue;S. Inokuchi;S. Kato

An artificial O2 carrier, liposome-encapsulated hemoglobin(LEH) as a plasma oxygenizer

人工 O2 载体、脂质体包裹的血红蛋白 (LEH) 作为血浆氧合剂

• 发表时间: 2008
• 作者: Kawaguchi AT;Fukumoto D;Haida M;Ogata Y;Tsukada H.
• 通讯作者: Tsukada H.

[○!A]循環補助薬

[○!A]循环辅助药

• 发表时间: 2011

HemoCD as an artificial oxygen carrier : Oxygen binding and autooxidation

HemoCD 作为人工氧载体：氧结合和自氧化

• 发表时间: 2009
• 期刊: Artif Organs
• 影响因子: 2.4
• 作者: Kano K;Kitagishi H;et al
• 通讯作者: et al

Liposome-encapsulated hemoglobin a improves energy metabolism in skeletal muscle ischemia and reperfusion in the rat

脂质体包裹的血红蛋白a改善大鼠骨骼肌缺血和再灌注的能量代谢

• 发表时间: 2012
• 期刊: Artificial Organs
• 影响因子: 2.4
• 作者: Daisuke Kurita;Akira T Kawaguchi;et al
• 通讯作者: et al