Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements

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We evaluated newly developed artificial oxygen carriers(AOCs), such as liposome-encapsulated hemoglobin(LEH), hemocyclodextrin, corphysene-myoglobin, in the animal models of various pathologic conditions derived from circulatory disorder. These AOCs, specifically LEH, have been proved to be protective of the organ function and morphologic structure in ischemia and/or reperfusion injury of the brain, cochlea and skeletal muscle. LEH is shown to be effective in accelerating wound healing in the stomach and skin. LEH is also shown to be inert and safe on intravenous infusion in mice reconstituted with human immune system. The mice remains immunologically intact and normally responding against third party antigens after transfused with a large amount of LEH(20 mL/kg), which may competitively inhibit the antigen processing activity of the host.