Basal ganglia outputs to the thalamus and cortex

我们研究了基底神经节的输出如何影响丘脑和运动皮层的活动，以及它们与运动障碍及其治疗的关系。基底神经节输出抑制丘脑活动。然而，重复的苍白球刺激有时会引起丘脑和皮层的兴奋。针对苍白球的脑深部电刺激的机制被认为是中断从基底节到丘脑的异常信息流。

We have investigated how the outputs from the basal ganglia contribute to the activity in the thalamus and motor cortices, and their relations to the movement disorders and their therapy. Basal ganglia outputs inhibit thalamic activity. However, repetitive pallidal stimulation sometimes induced excitation in the thalamus and cortex. The mechanism of deep brain stimulation targeting the globus pallidus was considered to be the interruption of abnormal information flow from the basal ganglia to the thalamus.