Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition
Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition
批准号:
21249007
负责人:
KISO Yoshiaki
金额:
$29.7万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
In order to develop therapeutics of difficult diseases based on molecular recognition, design of protease inhibitors based on the substrate transition state concept, elucidation of pathological mechanism of Alzheimer’s disease, its application to development of the therapeutics, identification of new physiologically active peptide, cryptides hidden in the protein sequences, and analysis of their signal transduction mechanism were carried out.
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Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.
在小四肽抑制剂中无需 P3-cap 部分即可保持有效的 HTLV-I 蛋白酶抑制作用。
DOI:
10.1016/j.bmcl.2011.01.048
发表时间:
2011
期刊:
Bioorg. Med. Chem. Lett.
影响因子:
--
作者:
[Jeffrey-Tri Nguyen, Keiko Kato, Henri-Obadja Kumada, Koushi Hidaka, Tooru Kimura, Yoshiaki Kiso]
通讯作者:
Yoshiaki Kiso
Defying difficult diseases: design and synthesis of aspartic protease in- hibitors and click peptides based on the O-acyl isopeptide method.
战胜疑难疾病:基于O-酰基异肽法设计合成天冬氨酸蛋白酶抑制剂和点击肽。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[T. Dohi, Y. Kita et al., 伊東 一良, Yoshiaki Kiso]
通讯作者:
Yoshiaki Kiso
Defying Difficult Diseases: Design and Synthesis of Transition-State Mimetic Protease Inhibitors.
对抗疑难疾病:过渡态模拟蛋白酶抑制剂的设计和合成。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Saitoh, N, Yoshiaki Kiso]
通讯作者:
Yoshiaki Kiso
タンパク質に隠された生理活性ペプチド「クリプタイド」が関わる新しい生体調節機構
一种新的生物调节机制,涉及隐藏在蛋白质中的生物活性肽“隐肽”
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[向井秀仁, 保苅義則, 関哲郎, 深水昭吉, 木曽良明]
通讯作者:
木曽良明
Mitocryptides : a novel family of neutrophil-activating peptides derived from mitochondrial proteins and their regulatory mechanisms.
Mitocryptides :源自线粒体蛋白及其调节机制的中性粒细胞激活肽的新家族。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[DOHI, Toshifumi, KITA, Yasuyuki, et al., H.Mukai]
通讯作者:
H.Mukai
共 86 条
Development of simple detection methods for ultra-trace phosphate in water
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批准号:20560504
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2008
-
负责人:KISO Yoshiaki
-
依托单位:
Design and medicinal chemistry research on drugs for difficult diseases based on molecular recognition of proteases
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批准号:18209005
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$22.8万
-
财政年份:2006
-
负责人:KISO Yoshiaki
-
依托单位:
Development of hazardous micro-pollutants with nanofiltaration membranes
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批准号:15360285
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.83万
-
财政年份:2003
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负责人:KISO Yoshiaki
-
依托单位:
Design and development of therapeutic drugs for intractable diseases based on molecular recognition of aspartic proteases
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批准号:15390039
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.04万
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财政年份:2003
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负责人:KISO Yoshiaki
-
依托单位:
Design of resistance-surmountable HIV protease inhibitors based on molecular recognition analysis of mutant protease
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批准号:12470508
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.04万
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财政年份:2000
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负责人:KISO Yoshiaki
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依托单位:
Study on strategy for AIDS drugs against mutant viruses
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批准号:10044327
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$6.53万
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财政年份:1998
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负责人:KISO Yoshiaki
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依托单位:
Molecular design of HIV protease inhibitors restricted to active conformation
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批准号:09557203
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.13万
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财政年份:1997
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负责人:KISO Yoshiaki
-
依托单位:
Joint Study on AIDS Drug Based on HIV Protease
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批准号:08044325
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$7.42万
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财政年份:1996
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负责人:KISO Yoshiaki
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依托单位:
Molecular design of AIDS therapeutics based on molecular recognition of enzymes.
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批准号:07308067
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$2.56万
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财政年份:1995
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负责人:KISO Yoshiaki
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依托单位:
A BASIC STUDY ON ADSORPTION PROPERTIES OF SOLUTE ON MEMBRANES AND CONTROL OF MEMBRANE FOULING
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批准号:07650639
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:KISO Yoshiaki
-
依托单位:
Joint study on protease-targeted anti-AIDS drugs
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批准号:05044191
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$10.24万
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财政年份:1993
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负责人:KISO Yoshiaki
-
依托单位:
海外基金