Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods

甲基汞（MeHg）和持久性有机污染物（POPs），如多氯联苯和滴滴涕，是环境持久性神经发育毒物。它们可以通过胎盘从母亲转移给胎儿，通过母乳喂养转移给婴儿。接触甲基汞和持久性有机污染物的主要来源是食物，特别是日本的鱼类和鱼类产品消费。我们之前进行了一项动物实验，以研究甲基汞和持久性有机污染物共同暴露对小鼠和豚鼠母婴动力学的影响。我们使用鲸油对甲基汞和持久性有机污染物进行暴露。p， p′-DDE-d8的添加也同样累积，d8为预测ddt的分布提供了一个有用的指标。我们观察了高污染持久性有机污染物油对小鼠睁眼和野外试验的负面影响。

Methylmercury (MeHg)and persistent organic pollutantspoly (POPs)such as PCBs and DDTs are environmentally persistent neurodevelopmental toxicants. They can be transferred from the mother to the fetus via palacenta and to the infant via breastfeeding. The main sources of the exposures to MeHg and POPs are food, particularly the consumption of fish and fish products in Japan. We previously carried out an animal experiment to examine the effect of co-exposure to MeHg and POPs on mother-to-child kinetics using mice and guinea pig. We administered MeHg and POPs using whale oil for POPs exposure. p, p'-DDE-d8 added was similarly accumulated and, d8 provided a useful index for predicting the distribution of DDTs. We observed negative effects on eye opening and open field test in group of mice of high contaminated POPs oil.