Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods

甲基汞(MeHg)和持久性有机污染物(POPs)，如多氯联苯和滴滴涕，是环境持久性神经发育毒物。它们可以通过宫殿从母亲传给胎儿，也可以通过母乳喂养传给婴儿。暴露于甲基汞和持久性有机污染物的主要来源是食品，特别是日本的鱼和鱼产品的消费。我们之前进行了一项动物实验，以考察甲基汞和持久性有机污染物联合暴露对母婴动力学的影响，使用小鼠和豚鼠。我们使用鲸鱼油对持久性有机污染物进行了甲基汞和持久性有机污染物的暴露。添加的p，p‘-DDE-d8也同样积累，d8为预测滴滴涕的分布提供了一个有用的指数。我们观察了高污染POPs油组对小鼠睁眼和旷场试验的负面影响。

Methylmercury (MeHg)and persistent organic pollutantspoly (POPs)such as PCBs and DDTs are environmentally persistent neurodevelopmental toxicants. They can be transferred from the mother to the fetus via palacenta and to the infant via breastfeeding. The main sources of the exposures to MeHg and POPs are food, particularly the consumption of fish and fish products in Japan. We previously carried out an animal experiment to examine the effect of co-exposure to MeHg and POPs on mother-to-child kinetics using mice and guinea pig. We administered MeHg and POPs using whale oil for POPs exposure. p, p'-DDE-d8 added was similarly accumulated and, d8 provided a useful index for predicting the distribution of DDTs. We observed negative effects on eye opening and open field test in group of mice of high contaminated POPs oil.