Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods

甲基汞（MeHg）和持久性有机污染物（POPs）如多氯联苯（PCBs）和滴滴涕（DDTs）是环境持久性神经发育毒物。它们可以通过Palacenta从母亲转移到胎儿，并通过母乳喂养转移到婴儿。在日本，甲基汞和持久性有机污染物的主要接触源是食物，特别是鱼和鱼产品的消费。我们以前进行了一项动物实验，以检查共同暴露于甲基汞和持久性有机污染物对母亲到孩子的动力学使用小鼠和豚鼠的影响。我们使用鲸油管理甲基汞和持久性有机污染物暴露。p，p '-DDE-d8也有类似的累积作用，d8为预测DDTs的分布提供了一个有用的指标。对高浓度染毒组小鼠进行了睁眼和旷场实验，观察到了明显的不良反应。

Methylmercury (MeHg)and persistent organic pollutantspoly (POPs)such as PCBs and DDTs are environmentally persistent neurodevelopmental toxicants. They can be transferred from the mother to the fetus via palacenta and to the infant via breastfeeding. The main sources of the exposures to MeHg and POPs are food, particularly the consumption of fish and fish products in Japan. We previously carried out an animal experiment to examine the effect of co-exposure to MeHg and POPs on mother-to-child kinetics using mice and guinea pig. We administered MeHg and POPs using whale oil for POPs exposure. p, p'-DDE-d8 added was similarly accumulated and, d8 provided a useful index for predicting the distribution of DDTs. We observed negative effects on eye opening and open field test in group of mice of high contaminated POPs oil.