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Study for intracellular direct effects of renin-angiotensin system in diabetic hearts

Study for intracellular direct effects of renin-angiotensin system in diabetic hearts
肾素-血管紧张素系统对糖尿病心脏细胞内直接作用的研究
批准号:
22590776
负责人:
SATOH Hiroshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
We studied the intracellular expression of non-secretary renin and (pro)renin receptor after ischemia, and the effects of renin on mitochondrial membrane potential in perfused hearts from diabetic (DM) and normal rats. In DM rats, non-secretary renin expressed at mitochondria could afford protective effectsagainst ischemic damage by preventing depolarization of mitochondrial membrane potential.We also examined additive effects of direct renin inhibitor (DRI) on lipid profiles and cytokines in diabetic patients with coronary arterial disease. The additional treatment with DRI decreased plasma renin activity and blood pressure, but did not provide any beneficial effects on lipid profiles or cytokines.
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DOI: 10.1016/j.niox.2011.12.007
发表时间: 2012-02-15
期刊: NITRIC OXIDE-BIOLOGY AND CHEMISTRY
影响因子: 3.9
作者: [Ohtani, Hayato, Katoh, Hideki, Hayashi, Hideharu]
通讯作者: Hayashi, Hideharu
The left ventricular pseudo-false aneurysm detected with ECG-gated multi-detector computed tomography and cardiac magnetic resonance imaging
心电门控多排计算机断层扫描和心脏磁共振成像检测左心室假性动脉瘤
DOI: --
发表时间: 2010
期刊: Circulation Journal
影响因子: 3.3
作者: [大谷速人, 佐藤 洋, 加藤秀樹, 早乙女雅夫 , 漆田 毅 , 林 秀晴]
通讯作者: 林 秀晴
Reactive Oxygen Species (ROS) from Excessive Mitochondrial Fatty Acid (FA) Oxidation Attenuates Myocardial Insulin-Signaling in Differentiated H9c2 Myocytes
线粒体脂肪酸 (FA) 过度氧化产生的活性氧 (ROS) 会减弱分化的 H9c2 肌细胞中的心肌胰岛素信号传导
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [宣原守, 早乙女雅夫, 漆田毅, 加藤秀樹, 佐藤洋, 林秀晴]
通讯作者: 林秀晴
Difference in the mechanism of left ventricular (LV) diastolic dysfunction between ischemic (ICM) and non-ischemic (DCM) dilated cardiomyopathy
缺血性(ICM)和非缺血性(DCM)扩张型心肌病左心室(LV)舒张功能障碍机制的差异
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [白木克典, 佐藤 洋, 加藤秀樹, 早乙女雅夫, 漆田 毅, 林 秀晴]
通讯作者: 林 秀晴
30
    Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods
    • 批准号:
      21249039
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $27.96万
    • 财政年份:
      2009
    • 负责人:
      SATOH Hiroshi
    • 依托单位:
    Does selenium deficiency deteriorate the effects of methylmercury exposure?
    • 批准号:
      18209022
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.12万
    • 财政年份:
      2006
    • 负责人:
      SATOH Hiroshi
    • 依托单位:
    Resumption of intracellular Ca2+ cycling as a novel therapeutic strategy for heart failure
    • 批准号:
      17590717
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.66万
    • 财政年份:
      2005
    • 负责人:
      SATOH Hiroshi
    • 依托单位:
    Study for detection of intracellular sodium transients and their pathophysiological roles in myocytes
    • 批准号:
      15590733
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2003
    • 负责人:
      SATOH Hiroshi
    • 依托单位: