Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy

为了阐明口腔癌的侵袭和转移机制，以便应用于基于分子的诊断和基因治疗，我们根据我们的项目进行了研究。因此，我们确定Wnt5B和MMP10是肿瘤侵袭的启动子，microRNA-203是肿瘤侵袭的抑制因子，Periostin是淋巴管生成的启动子，MMP13是血管生成的启动子。此外，我们还尝试将Periostin应用于口腔癌患者血清的检测。有趣的是，我们发现Periostin的上调与淋巴结转移状态有关。因此，我们认为Periostin可以作为口腔癌的分子诊断标记物。

To elucidate invasive and metastatic mechanism in oral cancer for application to molecular based diagnosis and gene therapy, we conducted research in accordance with our projects. As a result, we identified Wnt5B and MMP10 as promoter of , microRNA-203 as suppressor of tumor invasion, Periostin as promoter of lymphangiogenesis, MMP-13 as promoter of angiogenesis. Additionally, we attempted to apply Periostin to Elisa for serum of oral cancer patients. Interestingly, we found upregulation of Periostin correlated with lymphonode metastasis status. Therefore, we showed Periostin could be a useful for molecular diagnostic marker in oral cancer.