Development of novel therapeutic approach of rheumatoid arthritis with liposomalized lactoferrin

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Aim of the study was to clarify the effectiveness of liposomalized lactoferrin (L-Lf) as a new therapeutic agent of rheumatoid arthritis (RA). The following results were obtained.1. Administration of L-Lf significantly reduced the joint destruction observed in RA model mice. 2. Lf inhibited expression of inflammatory cytokines induced in human macrophages and synovial cells by TNF-a. Through inhibition of the map kinase and NFkb pathways 3. By oral administration of L-Lf decreased Th17 and increased Treg populations, and reduced IL-17 level in serum.These results show that l-lf could be used as a new therapeutic agent for RA.