Elucidation of new functions of intermediate filaments linking a relationship between proliferation and differentiation

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To uncover roles of intermediate filaments in proliferation and differentiation, we studied the functions of trichoplein, a keratin-binding protein, and trichoplein-related proteins. We found that trichoplein-Aurora-A pathway is required for G1 progression through a key role in the continuous suppression of primary cilia assembly. On the other hand, we revealed that knock-in mice expressing phosphodeficient vimentin variants developed binucleation and aneuploidy in lens epithelial cells, which promoted lens cataract, an aging phenotype.