Dynamic Property of Intermediate Filaments : Regulation by Phosphorylation

中间丝的动态特性：磷酸化的调节

• 批准号: 06454681
• 负责人: INAGAKI Masaki
• 金额: $ 3.9万
• 依托单位: Tokyo Metropolitan Institute of Gerontology (TMIG)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454681/
• 关键词: Intermediate Filament; Function; Phosphorylation; Protein Kinases; Visualization; Dynamic Property

Site-specific phosphory lation of intermediate filament (IF) proteins on serine and threoninc residues leads to alteration of the filament structure, in vitro and in vivo, Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation.Thus, IF phosphorylation appears to be one of the most predominant stratogy to coordinate intracellular organization of the IF network.

在体外和体内，丝氨酸和苏氨酸残基上的中间丝（IF）蛋白的位点特异性磷酸化导致丝结构的改变。参与细胞信号传导的蛋白激酶和在有丝分裂中活化的蛋白激酶动态地控制细胞内IF磷酸化的空间和时间组织。IF磷酸化似乎是协调IF网络的细胞内组织的最主要策略之一。

项目成果

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Shinobu Oumi、Kunio Tsujimura、Masaki Inagaki：“细胞工程特卷抗肽抗体实验方案” Shujunsha，215（1994）