Dynamic Property of Intermediate Filaments : Regulation by Phosphorylation
Dynamic Property of Intermediate Filaments : Regulation by Phosphorylation
批准号:
06454681
负责人:
INAGAKI Masaki
金额:
$3.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1994
资助国家:
日本
项目状态:
已结题
起止时间:
1994 至 1995
中文摘要
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英文摘要
Site-specific phosphory lation of intermediate filament (IF) proteins on serine and threoninc residues leads to alteration of the filament structure, in vitro and in vivo, Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation.Thus, IF phosphorylation appears to be one of the most predominant stratogy to coordinate intracellular organization of the IF network.
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大海忍 辻村邦夫 稲垣昌樹: "細胞工学 別冊 抗ペプチド抗体実験プロトコール" 秀潤社, 215 (1994)
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共 16 条
Elucidation of new functions of intermediate filaments linking a relationship between proliferation and differentiation
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Elucidation of the protein phosphorylation signaling and the regulatory mechanism of cytoskeleton
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Regulatory mechanisms of cytoskeletal proteins by phosphorylation and their cellular functions
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Analysis of Intermediate Filament Binding Proteins
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Function and regulation of intermediate filament organization during cell prolifenation and cell signalings.
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依托单位:
Role of cytoskeletal proteins phosphorylation on their cellular functions.
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国内基金
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