Antinomy of cell-cell adhesion and cell proliferation

我们研究了三角蛋白和信天翁与角蛋白中间丝结合的功能。我们发现角蛋白和信天翁蛋白在上皮细胞的极化中起重要作用，而Trichoplein定位于中心体，参与初级纤毛形成的调控。另一方面，我们通过磷酸化发现了Chk1的新调控机制，Chk1在DNA损伤检查点中具有重要功能。

We studied the functions of Trichoplein and Albatross that bind to keratin intermediate filaments. We found that keratin and Albatross play an important role in the polarization of epithelial cells, and that Trichoplein is localized at centrosomes and is involved in the regulation of primary cilia formation. On the other hand, we found novel regulatory mechanisms of Chk1, which has important functions in the DNA damage checkpoint, via its phosphorylation.